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Losartan

(Synonyms: DuP-753)
59 Cited Publications
고객리뷰

Based on 59 publication(s) in Google Scholar

Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

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  • Purity: 99.41%
  • CAS No.: 114798-26-4
  • 화학식: C22H23ClN6O
  • 분자량:422.91
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Losartan Chemical Structure
    Losartan Chemical Structure
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
  • Experimental Validation Results for Losartan
CAS No.: 114798-26-4
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Publications Citing Use of MedChemExpress (MCE) Losartan

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Cell Proliferation/Viability AssayIn Vivo Efficacy StudyApoptosis AnalysisCell Migration/Invasion AssayIHCRT-PCRIFWB
  • In Vivo Efficacy Study
  • Cell Proliferation/Viability Assay
  • In Vivo Efficacy Study
  • Cell Proliferation/Viability Assay
  • Apoptosis Analysis
  • Cell Migration/Invasion Assay
  • RT-PCR
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  • In Vivo Efficacy Study
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  • Losartan Chemical Structure
    Losartan Chemical Structure
    1/16
  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 25;16(1):10430. [Abstract]

    Customer Validation
     Blood glucose levels were significantly reduced in EMP-treated mice but remained unchanged with Losartan potassium (LOS, oral, 10 mg/kg/day) treatment.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Dec 3:136:156314. [Abstract]

    Customer Validation
     The CCK-8 assay was performed to determine cell viability after Losartan potassium treatment under HG conditions for 48 h.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Dec 3:136:156314. [Abstract]

    Customer Validation
     The kidney/body weight ratios demonstrated that both Losartan potassium and PHI exerted nephroprotective effects against DN, with H-PHI treatment exhibiting a greater effect.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Sep 6;12(9):e009327. [Abstract]

    Customer Validation
     Proliferation ability of MDA-MB-231 and HS578T cells in control and Losartan (10µM)-treated groups was assessed by colony formation assay.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Sep 6;12(9):e009327. [Abstract]

    Customer Validation
     Apoptosis level of MDA-MB-231 and HS578T cells in control and Losartan (10µM)-treated groups was assessed by flow cytometry assay.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Sep 6;12(9):e009327. [Abstract]

    Customer Validation
     Migration ability of MDA-MB-231 and HS578T cells in control and Losartan (10µM)-treated groups were assessed by Boyden chamber assay.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Sep 6;12(9):e009327. [Abstract]

    Customer Validation
     Expression of COL1A1 in control and Losartan (10µM)-treated CAFs was assessed by qPCR and Western blotting assays.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Sep 6;12(9):e009327. [Abstract]

    Customer Validation
     Expression of COL1A1 in control and Losartan (10µM)-treated CAFs was assessed by immunofluorescence assay.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 May 22;11(5):390. [Abstract]

    Customer Validation
     Both dapagliflozin and Losartan potassium treatment significantly reduced the urinary albumin levels at 12 weeks.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 May 22;11(5):390. [Abstract]

    Customer Validation
     Both dapagliflozin and Losartan potassium treatment significantly reduced the NGAL levels at 12 weeks.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 May 22;11(5):390. [Abstract]

    Customer Validation
     Morphological analysis revealed that glomerular tuft area , mesangial expansion, and mesangial matrix hyperplasia (fractional mesangial area, FMA), which were increased in diabetic mice, were also equally improved by dapagliflozin and Losartan potassium treatment.

  • 1/16

    Losartan purchased from MedChemExpress. Usage Cited in: FASEB J. 2018 Sep;32(9):5051-5062. [Abstract]

    Customer Validation
     HUVECs are starved for 12 h, treated with 10 mg/mL (9.56 μM) of AngII with or without Losartan or PD123319 for 12 h, and are subsequently used for Western blot analysis.

  • Losartan