ALD-52
ALD-52 (1-Acetyl-LSD) is a prodrug for LSD. ALD-52 shows an affinity to 5-HT1A, 5-HT2A and 5-HT2C with a sub>D values of 1054, 174 and 10.2 nM, respectively. ALD-52 is converted to LSD and induces a head-twitch response (HTR) in vivo. ALD-52 can be used for hallucinogen research.
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- CAS No.: 3270-02-8
- 화학식: C22H27N3O2
- 분자량:365.47
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
ALD-52 shows an affinity to 5-HT1A, 5-HT2A and 5-HT2C with a sub>D values of 1054, 174 and 10.2 nM, respectively[1].
ALD-52 acts as very weak partial agonists at the human 5-HT2A receptor with an EC50 value of 38 nM and an Emax value of 25%, shows slightly higher potency and efficacy at m5-HT2A< /sub> with an EC50 value of 12 nM and an Emax value of 19%, shows no agonist activity at h5-HT2B and h5-HT2C in HEK cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ALD-52 (0.1-0.3 mg/kg, s.c., once) produces LSD plasma concentrations of 35.5 and 103.8 ng/mL in Sprague Dawley rats, respectively[1].
ALD-52 (0.3 mg/kg, s.c., once) has biotransformation with multipathway and does not simply involve complete conversion to LSD (undergoes N deethylation, N6 demethylation, and hydroxylation, yielding two phenolic metabolites) in Sprague Dawley rats (consistent results were obtained using the in vitro human liver homogenate system.)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3270-02-8
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분자량 365.47
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화학식 C22H27N3O2
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SMILES
[H][C@@]1(N(C)C[C@H](C(N(CC)CC)=O)C=C12)CC3=CN(C(C)=O)C4=C3C2=CC=C4
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Synonyms
1-Acetyl-LSD
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Halberstadt AL, et al .Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD). Neuropharmacology. 2020 Aug 1;172:107856. [Content Brief]
[2]. Zhang SH, et al. Stability studies of ALD-52 and its homologue 1P-LSD. J Forensic Sci. 2023 May;68(3):1009-1019. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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