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Cat. No.: HY-146769

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Antimalarial agent 11

Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC₅₀ of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC₅₀s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively.

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CAS No.: 1214454-56-4
화학식: C₂₅H₂₅F₂NO₃
분자량:425.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Antimalarial agent 11 Chemical Structure

CAS No.: 1214454-56-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- Cellular Effect
Chemical Information
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Calculators
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Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	>20 μM Compound: 1	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 35091169]
HepG2	EC₅₀	19 μM Compound: 64	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 33069128]
HepG2	EC₅₀	19 μM Compound: 82	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay	[PMID: 35461019]

Chemical Information

CAS No. 1214454-56-4
분자량 425.47
화학식 C₂₅H₂₅F₂NO₃
SMILES

OC(CN1CCC2(CC(O)C3=C(O2)C4=C(C=CC=C4)C=C3)CC1)C5=CC=C(F)C(F)=C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Iredia D Iyamu, et al. Structure-activity and structure-property relationship studies of spirocyclic chromanes with antimalarial activity. Bioorg Med Chem. 2022 Mar 1;57:116629. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
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Antimalarial agent 11

All Parasite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Antimalarial agent 11 Related Classifications

HY-146769 Related Classifications