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United States

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Cat. No.: HY-182907

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Antimalarial agent 60

Antimalarial agent 60 is an antimalarial agent with an IC₅₀ of 116.2 nM against asexual blood-stage parasites of Plasmodium falciparum 3D7. Antimalarial agent 60 can be used in malaria research.

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화학식: C₁₈H₁₃F₄N₃O₃
분자량:395.31

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antimalarial agent 60 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

In Vitro

Antimalarial agent 60 (Compound 53) (1-10 μM; 72 h) potently inhibits the asexual blood-stage Plasmodium falciparum strain 3D7, with an IC₅₀ of 116.2 nM; meanwhile, this compound exhibits extremely low cytotoxicity against human HepG2 cells, with a CC₅₀ > 20 μM and a selectivity index > 170^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 395.31
화학식 C₁₈H₁₃F₄N₃O₃
SMILES

FC1=C(F)C=C(NC(N(C(CC)C(NC2=CC=C(F)C(F)=C2)=O)C3=O)=O)C3=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Lohawittayanan D, et al. From Hit to Lead: Systematic Optimization of the Quinazolinedione Scaffold as Potent and Noncytotoxic Antimalarial Agents. ACS omega. 2026 Apr 21;11(15):22796-22806. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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