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Cat. No.: HY-189011

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FPPS-IN-3

FPPS-IN-3 is an FPPS inhibitor with an IC₅₀ of 7.75 µM (Leishmania major) and exhibits antimalarial activity. FPPS-IN-3 also inhibits PFK activity. FPPS-IN-3 inhibits the growth of Entamoeba histolytica and Plasmodium falciparum. FPPS-IN-3 is cytotoxic to nasopharyngeal carcinoma cells. FPPS-IN-3 can be used for research on amoebiasis and malaria.

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CAS No.: 16610-63-2
화학식: C₁₂H₂₈O₇P₂
분자량:346.29

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

FPPS-IN-3 Chemical Structure

CAS No.: 16610-63-2

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
KB	LD₅₀	492 μM	Cytotoxicity against human KB nasopharyngeal carcinoma cells. Cytotoxicity against human KB nasopharyngeal carcinoma cells.	14695831

In Vitro

Anti-cancerParasitic Infection

Anti-cancer

FPPS-IN-3 exhibits an LD₅₀ of 492 µM against human KB nasopharyngeal carcinoma cells^[1].

Parasitic Infection

FPPS-IN-3 (Compound 8) (0-150 µM; incubation for 90 h, followed by incubation with [³H]hypoxanthine for 6 h) inhibits the growth of Entamoeba histolytica HM-1:IMSS with an IC₅₀ of 63.7 µM^[1].
FPPS-IN-3 (48 h) inhibits the intraerythrocytic growth of P. falciparum 3D7 with an IC₅₀ of 1.07 µM^[1].
FPPS-IN-3 inhibits Leishmania major FPPS with an IC₅₀ of 7.75 µM^[1].
FPPS-IN-3 inhibits the expressed E. histolytica PPi-PFK with an IC₅₀ of 40 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

CAS No. 16610-63-2
분자량 346.29
화학식 C₁₂H₂₈O₇P₂
SMILES

O=P(O)(C(CCCCCCCCCCC)(P(O)(O)=O)O)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Ghosh S, et al. Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. Journal of medicinal chemistry. 2004 Jan 01;47(1):175-87. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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