ATL 1102
ATL 1102 (Avicursen) is a novel second-generation antisense oligonucleotide to CD49d mRNA
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- CAS No.: 350263-41-1
- 분자량:7230.14
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
제품 설명
Chemical Information
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CAS No. 350263-41-1
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분자량 7230.14
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SMILES
[ATL 1102]
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Synonyms
ISIS-107248; Avicursen
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
순도&문서
References
[1]. Duchartre Y, Bachl S, Kim HN, et al. Effects of CD49d-targeted antisense-oligonucleotide on α4 integrin expression and function of acute lymphoblastic leukemia cells: Results of in vitro and in vivo studies. PLoS One. 2017;12(11):e0187684. [Content Brief]
[2]. Limmroth V, Barkhof F, Desem N, Diamond MP, Tachas G; ATL1102 Study Group. CD49d antisense drug ATL1102 reduces disease activity in patients with relapsing-remitting MS [published correction appears in Neurology. 2015 Jan 6;84(1):105]. Neurology. 2014;83(20):1780-1788. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)