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Cat. No.: HY-188382

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AuPROTAC

AuPROTAC is a dual MERTK and TXNL1 PROTAC degrader containing a cyclometalated Au (III) complex. AuPROTAC specifically covalently binds the target proteins MERTK and TXNL1 through a gold-template-based two-step mechanism (gold-thiol coordination and cysteine arylation), while recruiting the CRBN E3 ubiquitin ligase to form a ternary complex, mediating the ubiquitination and degradation of MERTK and TXNL1. AuPROTAC can be used for research on acute myeloid leukemia.
(Pink: TXNL1 and MERTK ligand (HY-188383); Blue: Cereblon ligand (HY-14658); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₃₃H₃₂AuCl₂N₇O₆
분자량:890.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (285 KB)

AuPROTAC Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

AuPROTAC is a dual MERTK and TXNL1 PROTAC degrader containing a cyclometalated Au (III) complex. AuPROTAC specifically covalently binds the target proteins MERTK and TXNL1 through a gold-template-based two-step mechanism (gold-thiol coordination and cysteine arylation), while recruiting the CRBN E3 ubiquitin ligase to form a ternary complex, mediating the ubiquitination and degradation of MERTK and TXNL1. AuPROTAC can be used for research on acute myeloid leukemia^[1]. (Pink: TXNL1 and MERTK ligand (HY-188383); Blue: Cereblon ligand (HY-14658); Black: linker).

IC₅₀ & Target

^[1]

MERTK

TXNL1

Cereblon

All PROTACs Isoforms :

All TAM Receptor Isoforms :

All TrxR Isoforms :

TrxR1
TrxR2

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	58.5 μM	Cytotoxicity against PMA-differentiated HL-60 cells assessed as viability reduction incubated 24 hrs by dose-response assay. Cytotoxicity against PMA-differentiated HL-60 cells assessed as viability reduction incubated 24 hrs by dose-response assay.	41486557

In Vitro

Anti-cancerProtein/Amino Acid Metabolism

Anti-cancer

AuPROTAC (24 h) reduces the viability of PMA (HY-18739)-differentiated HL-60 cells with an IC₅₀ of 58.5 µM^[1].
AuPROTAC (8 h) reduces the viability of PMA-differentiated HL-60 cells in the presence of CHX (HY-12320), with an IC₅₀ of 64.3 µM^[1].
AuPROTAC (60 μM; 0.5-8 h) combined with 10 μM CHX quantitatively degrades MERTK and TXNL1 and partially degrades SLC3A2 and NOTCH2 in PMA-differentiated HL-60 cells^[1].

Protein/Amino Acid Metabolism

AuPROTAC alters the half-life of proteins in HL-60 cells in the presence of CHX, including shortening FLNA to 23.8 h and NOTCH2 to 1.8 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 890.52
화학식 C₃₃H₃₂AuCl₂N₇O₆
SMILES

O=C1C(CCC(N1)=O)N2C(C3=C(C(N4CCN(CCNC(CO/N=C5C6=CC=CC=[C-]6[Au+3]([Cl-])([Cl-])[N]7=C/5C=CC=C7)=O)CC4)=CC=C3)C2=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thomas SR, et al. A Gold-PROTAC Degrades the Oncogenic Tyrosine Kinase MERTK: Insights into the Degradome from a Steady-State System. ACS chemical biology. 2026 Jan 16;21(1):170-186.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

AuPROTAC

All PROTACs Isoforms

All TAM Receptor Isoforms

All TrxR Isoforms