BIBO3304 diTFA
Based on 4 publication(s) in Google Scholar
BIBO3304 (diTFA) is an orally effective and selective neuropeptide Y (NPY) Y1 receptor antagonist. BIBO3304 (diTFA) has a high affinity for both human and rat Y1 receptors, with IC50 values of 0.38 and 0.72 nM, respectively. BIBO3304 (diTFA) promotes bone-tendon healing through the Wnt/β-catenin signaling pathway.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 2310085-85-7
- 화학식: C33H37F6N7O7
- 분자량:757.68
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) BIBO3304 diTFA
More-
Others
-
In Vivo Efficacy Study
-
Others
All Neuropeptide Y Receptor Isoforms
More
Biological Activity
Chemical Information
-
CAS No. 2310085-85-7
-
분자량 757.68
-
화학식 C33H37F6N7O7
-
SMILES
O=C(N[C@@H](C(NCC1=CC=C(CNC(N)=O)C=C1)=O)CCCNC(N)=N)C(C2=CC=CC=C2)C3=CC=CC=C3.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
-
Journal Impact Factor
-
Most Recent
-
Nat Commun
Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord. [Abstract]2025 Aug 1;16(1):7074. PMID: 40750771
BIBO3304 diTFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 1;16(1):7074. [Abstract]
Intrathecal injection of NPY1R selective antagonist BIBO3304 (BIBO, 10 μg, 20 min before) blocked the effects of LP-NPY (3 μg) on morphine-induced itch, one-way ANOVA, Dunnett’s multiple comparisons.
BIBO3304 diTFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 1;16(1):7074. [Abstract]
NPY (10 μM) induced outward currents were recorded and inhibited by BIBO3304(2 μM) from GRP+ interneurons in the SDH from GrpCre;Ai9 mice.
-
Nat Commun
2024 Sep 1;15(1):7603. PMID: 39217143 -
Brain
2026 Feb 25:awag077. PMID: 41738433 -
In Vivo
Ghrelin Induces the Production of Hypothalamic NPY Through the AMPK-mTOR Pathway to Alleviate Cancer-induced Bone Pain. [Abstract]2024 May-Jun;38(3):1133-1142. PMID: 38688635
BIBO3304 diTFA purchased from MedChemExpress. Usage Cited in: In Vivo. 2024 May-Jun;38(3):1133-1142. [Abstract]
Hypothalamic NPY exerted an antinociceptive effect by binding to Y1R and Y2R in cancer-bearing rats. PWT was measured using von Frey filaments (BIBO3304: 3 μg).
순도&문서
References
[1]. Wieland HA, et al. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br J Pharmacol. 1998 Oct;125(3):549-55. [Content Brief]
[2]. Loh K, et al. Inhibition of Y1 receptor signaling improves islet transplant outcome. Nat Commun. 2017 Sep 8;8(1):490. [Content Brief]
[3]. Chen Y, et al. Early treadmill running delays rotator cuff healing via Neuropeptide Y mediated inactivation of the Wnt/β-catenin signaling. J Orthop Translat. 2021 Oct 11;30:103-111. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)