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Cat. No.: HY-19397

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BMS-223131

BMS-223131 (Compound 1) is a potent maxi-K potassium channel opener. BMS-223131 has a strong inhibitory effect on the CYP2C9 enzyme (IC₅₀ = 1.7 μM) and also shows varying degrees of inhibition on other common CYP enzymes such as CYP1A2, CYP2C19, CYP2D6, and CYP3A4. BMS-223131 can enhance the outward current mediated by maxi-K, by promoting K⁺ efflux to hyperpolarize the cell membrane and reducing Ca²⁺ influx. BMS-223131 can be used for the research of neurological disease, such as stroke.

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CAS No.: 275375-69-4
화학식: C₁₈H₁₃ClF₃NO₃
분자량:383.75

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

BMS-223131 Chemical Structure

CAS No.: 275375-69-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

CYP2C9

1.7 μM (IC₅₀)

CYP1A2

CYP2C19

CYP2D6

CYP3A4

All Cytochrome P450 Isoforms :

Chemical Information

CAS No. 275375-69-4
분자량 383.75
화학식 C₁₈H₁₃ClF₃NO₃
SMILES

O=C1NC2=C(C=C(C(F)(F)F)C=C2)C(C3=CC(Cl)=CC=C3O)=C1CCO
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vrudhula VM, et al. Analogs of a potent maxi-K potassium channel opener with an improved inhibitory profile toward cytochrome P450 isozymes. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4286-90. [Content Brief]

Calculators

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Mass Mass

Concentration Concentration

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Concentration _(start) Concentration _(start)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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BMS-223131

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

BMS-223131 Related Classifications

HY-19397 Related Classifications