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Cat. No.: HY-141843

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BRD4-IN-2

BRD4-IN-2 is a bromodomain BRD4 inhibitor with an IC₅₀ value of 9.9 nM.

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CAS No.: 2679925-55-2
화학식: C₄₃H₄₈N₈O₁₁
분자량:852.89

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

BRD4-IN-2 Chemical Structure

CAS No.: 2679925-55-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
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Biological Activity

제품 설명

BRD4-IN-2 is a bromodomain BRD4 inhibitor with an IC₅₀ value of 9.9 nM.

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Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	16.9 nM Compound: 2	Protac activity at Halo-tagged CRBN/Nanoluc fused BRD4 in human HEK293 cells using nano-glo as substrate preincubated for 1 hr followed by substrate addition and measured after 3 min by NanoBRET assay Protac activity at Halo-tagged CRBN/Nanoluc fused BRD4 in human HEK293 cells using nano-glo as substrate preincubated for 1 hr followed by substrate addition and measured after 3 min by NanoBRET assay	[PMID: 36170570]

Chemical Information

CAS No. 2679925-55-2
분자량 852.89
화학식 C₄₃H₄₈N₈O₁₁
SMILES

CNC(N1N=C(C2=C(C[C@@H]1C)C=C(C(OC)=C2)OC)C3=CC=C(C=C3)N4CCN(CC4)C(COCCOCC(NC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sabnis RW. Substituted 2,3-Benzodiazepines Derivatives as Bromodomain BRD4 Inhibitors. ACS Med Chem Lett. 2021 Sep 28;12(10):1530-1531. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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BRD4-IN-2

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