CAA-0225
CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC50 value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites[1][2][3].
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- CAS No.: 244072-26-2
- 화학식: C28H29N3O5
- 분자량:487.55
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
All Cathepsin Isoforms
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Biological Activity
제품 설명
IC50 & Target
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cathepsin L |
In Vitro
CAA-0225 (10 mg/mL, 4 h) acts as a probe for autophagic protein hydrolysis by specifically inhibiting the involvement of protease L in the degradation of autophagosome membrane markers LC3-II and GABARAP[1]. CAA-0225 (0-100 μM, 48 h) kills Trypanosoma brucei parasite by inhibiting tissue protease L[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa、Huh-7 cells
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Concentration:10 mg/mL
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Incubation Time:4 h
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Result:Inhibited the degradation of microtubule associated protein IA/IB light chain 3-II (LC3-II) and gamma aminobutyric acid (A) receptor associated protein (GABARAP)-II
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Cell Line:Bloodstream forms of T. brucei clone 427–221a
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Concentration:0-100 μM
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Incubation Time:48 h
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Result:Inhibited the growth of trypanosomes in a dose-dependent manner with GI50 values of 0.33 μM, respectively
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Model of reperfusion injury involved male C57Bl/6 mice aged 9–12 weeks[2].
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Dosage:0.25 mg
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Administration:Intravenous injection (i.v.)
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Result:Reduced infarct size, improved systolic and diastolic cardiac function.
Chemical Information
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CAS No. 244072-26-2
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분자량 487.55
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화학식 C28H29N3O5
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SMILES
O=C([C@H]1O[C@@H]1C(N[C@@H](CC2=CC=CC=C2)C(NCC3=CC=CC=C3)=O)=O)NCCC4=CC=C(O)C=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAA-0225 Related Classifications
HY-16121 Related Classifications
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