Cholesterol-d4
Based on 1 publication(s) in Google Scholar
Cholesterol-d4 is deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.
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- Purity: 99.26%
- CAS No.: 956029-28-0
- 화학식: C27H42D4O
- 분자량:390.68
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cholesterol-d4
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 956029-28-0
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Unlabeled Cas 57-88-5
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Appearance Solid
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분자량 390.68
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화학식 C27H42D4O
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Color White to off-white
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SMILES
O[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H]([C@@H](CCCC([2H])(C)C([2H])([2H])[2H])C)CC[C@@]4([H])[C@]3([H])CC=C2C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Neurodegener
Preclinical studies and transcriptome analysis in a model of Parkinson's disease with dopaminergic ZNF746 expression. [Abstract]2025 Feb 28;20(1):24. PMID: 40022229
용액&용해도
Ethanol : 20 mg/mL (51.19 mM; Need ultrasonic)
DMSO : 1 mg/mL (2.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Casaburi I, et al. Cholesterol as an Endogenous ERRα Agonist: A New Perspective to Cancer Treatment. Front Endocrinol (Lausanne). 2018 Sep 11;9:525. [Content Brief]
[2]. Dietschy JM, et al. Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res. 2004 Aug;45(8):1375-97. [Content Brief]
[3]. Fukui K, et al. Effect of Cholesterol Reduction on Receptor Signaling in Neurons. J Biol Chem. 2015 Sep 14. [Content Brief]
[4]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / Ethanol | 1 mM | 2.5596 mL | 12.7982 mL | 25.5964 mL | 63.9910 mL |
| Ethanol | 5 mM | 0.5119 mL | 2.5596 mL | 5.1193 mL | 12.7982 mL |
| 10 mM | 0.2560 mL | 1.2798 mL | 2.5596 mL | 6.3991 mL | |
| 15 mM | 0.1706 mL | 0.8532 mL | 1.7064 mL | 4.2661 mL | |
| 20 mM | 0.1280 mL | 0.6399 mL | 1.2798 mL | 3.1995 mL | |
| 25 mM | 0.1024 mL | 0.5119 mL | 1.0239 mL | 2.5596 mL | |
| 30 mM | 0.0853 mL | 0.4266 mL | 0.8532 mL | 2.1330 mL | |
| 40 mM | 0.0640 mL | 0.3200 mL | 0.6399 mL | 1.5998 mL | |
| 50 mM | 0.0512 mL | 0.2560 mL | 0.5119 mL | 1.2798 mL |
Cholesterol-d4 Related Classifications
HY-N0322S6 Related Classifications
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