Chromeceptin
Based on 2 publication(s) in Google Scholar
Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR.
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- Purity : 99.80%
- CAS No.: 331859-86-0
- 화학식: C19H16F3N3O
- 분자량:359.35
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Chromeceptin
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Biological Activity
제품 설명
In Vitro
Chromeceptin (94G6) (5 μM) inhibits IGF2 expression in Hep3B-derived TS cells in a time-dependent manner[1].
Chromeceptin decreases the Phosphorylation levels of protein kinase B (AKT, Ser463) and rapamycin (mTOR, Ser 2481 and Ser 2448) in TS cells[1].
Chromeceptin represses the phosphorylation at ser371 in mTOR effectors ribosomal protein S6 kinase (p70S6K)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 331859-86-0
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Appearance Solid
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분자량 359.35
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화학식 C19H16F3N3O
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Color White to light yellow
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SMILES
N#CC1=C(N)OC2=CC(N(C)C)=CC=C2C1C3=CC=CC(C(F)(F)F)=C3
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Synonyms
94G6
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Biol Sci
Mechanical stretch-induced IGF2 overexpression in epidermal keratinocytes promotes hypertrophic scar formation through the IGF1R/p-c-Jun axis. [Abstract]2025 Jan 1;21(1):109-127. PMID: 39744430 -
용액&용해도
In Vitro:
DMSO : 100 mg/mL (278.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 10 mg/mL (27.83 mM); Suspended solution; Need ultrasonic
순도&문서
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.7828 mL | 13.9140 mL | 27.8280 mL | 69.5701 mL |
| 5 mM | 0.5566 mL | 2.7828 mL | 5.5656 mL | 13.9140 mL | |
| 10 mM | 0.2783 mL | 1.3914 mL | 2.7828 mL | 6.9570 mL | |
| 15 mM | 0.1855 mL | 0.9276 mL | 1.8552 mL | 4.6380 mL | |
| 20 mM | 0.1391 mL | 0.6957 mL | 1.3914 mL | 3.4785 mL | |
| 25 mM | 0.1113 mL | 0.5566 mL | 1.1131 mL | 2.7828 mL | |
| 30 mM | 0.0928 mL | 0.4638 mL | 0.9276 mL | 2.3190 mL | |
| 40 mM | 0.0696 mL | 0.3479 mL | 0.6957 mL | 1.7393 mL | |
| 50 mM | 0.0557 mL | 0.2783 mL | 0.5566 mL | 1.3914 mL | |
| 60 mM | 0.0464 mL | 0.2319 mL | 0.4638 mL | 1.1595 mL | |
| 80 mM | 0.0348 mL | 0.1739 mL | 0.3479 mL | 0.8696 mL | |
| 100 mM | 0.0278 mL | 0.1391 mL | 0.2783 mL | 0.6957 mL |
Chromeceptin Related Classifications
HY-115449 Related Classifications
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