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Cat. No.: HY-146364

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CI-39

CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an EC₅₀ of 3.40 μM and an CC₅₀ of >30 μM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2132412-25-8
화학식: C₁₉H₁₈N₂O₄
분자량:338.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

CI-39 Chemical Structure

CAS No.: 2132412-25-8

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

HIV-1 (WT)

3.40 μM (EC₅₀)

DNA Polymerase

HIV-1 (WT)

>30 μM (CC₅₀)

All DNA/RNA Synthesis Isoforms :

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	>30 μM Compound: Cl-39	Cytotoxicity against human HEK 293T cells assessed as reduction in cell viability measured after 48 hrs by Celltiter-glo assay Cytotoxicity against human HEK 293T cells assessed as reduction in cell viability measured after 48 hrs by Celltiter-glo assay	[PMID: 32004936]

In Vitro

CI-39 (0-100 μM) inhibits HIV-1 RT DNA polymerase and ribonuclease H activities with EC₅₀s of 7.20, >30 μM, respectively^[1].
CI-39 shows antiviral activities with EC₅₀s of 3.37, 3.00, 2.41, 3.08, 2.14, 3.27, 3.19, 4.07 μM for VSVG/HIV-1_wt, VSVG/HIV-1_RT-K103N, VSVG/HIV-1_wtRT-K103N, VSVG/HIV-1RT-K1_RT-Y181C, VSVG/HIV-1RT-K1_{RT-K103N,Y181C}, VSVG/HIV-1_{RT-K103N,Y181C}, VSVG/HIV-1_{RT-L100I,K103N}, VSVG/HIV-1_RT-Y188L, VSVG/HIV-1_{RT-K103N,G190A}, VSVG/HIV-1_{RT-K103N,V108I}, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2132412-25-8
분자량 338.36
화학식 C₁₉H₁₈N₂O₄
SMILES

O=C(CC1=CN(C2=C1C=CC=C2)OC)NC3=C(C(OC)=O)C=CC=C3
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu C, et al. Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root. Eur J Med Chem. 2020 Mar 1;189:112071. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

CI-39

All DNA/RNA Synthesis Isoforms

All HIV Isoforms