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Cat. No.: HY-100349A

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cis-SU4312

(Synonyms: (Z)-SU4312)

cis-SU4312 ((Z)-SU4312) inhibits PDGFR and FLK-1 with IC₅₀s of 19.4 and 0.8 μM, respectively. cis-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC₅₀s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively. cis-SU4312 can cross blood brain barrier.

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CAS No.: 90828-16-3
화학식: C₁₇H₁₆N₂O
분자량:264.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

cis-SU4312 Chemical Structure

CAS No.: 90828-16-3

사이즈

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All PDGFR Isoforms :

All VEGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	3.75 μM Compound: 20, SU-4312	Inhibition of PDGFRbeta expressed in human A431 cells Inhibition of PDGFRbeta expressed in human A431 cells	[PMID: 20558072]
SF-539	IC₅₀	3.7 μM Compound: 22, DMBI	Inhibition of PDGFRbeta in human SF539 cells assessed as inhibition of PDGFR-BB-induced tyrosine phosphorylation incubated for 60 mins prior to EGF-activation measured 10 mins by ELISA Inhibition of PDGFRbeta in human SF539 cells assessed as inhibition of PDGFR-BB-induced tyrosine phosphorylation incubated for 60 mins prior to EGF-activation measured 10 mins by ELISA	[PMID: 23434139]
SF-539	IC₅₀	3.7 μM Compound: 50, DMBI	Inhibition of PDGFRbeta phosphorylation in human SF539 cells after 10 mins by FLISA Inhibition of PDGFRbeta phosphorylation in human SF539 cells after 10 mins by FLISA	[PMID: 20403700]
SF-539	IC₅₀	3.75 μM Compound: 19, SU-4312	Inhibition of PDGFRbeta in human SF539 cells pretreated for 60 mins measured after 1 hr by ELISA Inhibition of PDGFRbeta in human SF539 cells pretreated for 60 mins measured after 1 hr by ELISA	[PMID: 22739090]
SF-539	IC₅₀	3.75 μM Compound: 21, DMBI	Inhibition of PDGFRbeta tyrosine kinase activity in PDGF-BB-stimulated human SF-539 cells after 60 mins by ELISA Inhibition of PDGFRbeta tyrosine kinase activity in PDGF-BB-stimulated human SF-539 cells after 60 mins by ELISA	[PMID: 22204741]
SF-539	IC₅₀	3.75 μM Compound: DMBI	Inhibition of PDGFRbeta in human SF539 cells by phosphotyrosine cell-based ELISA Inhibition of PDGFRbeta in human SF539 cells by phosphotyrosine cell-based ELISA	[PMID: 20092323]
Sf9	IC₅₀	>100 μM Compound: 43	Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cells Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cells	[PMID: 20117004]

Chemical Information

CAS No. 90828-16-3
분자량 264.32
화학식 C₁₇H₁₆N₂O
SMILES

O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(N(C)C)C=C3
Synonyms

(Z)-SU4312
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wei Cui, et al. The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Br J Pharmacol. 2013 Mar;168(5):1201-14. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

cis-SU4312

All PDGFR Isoforms

All VEGFR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

cis-SU4312 Related Classifications

HY-100349A Related Classifications