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Cat. No.: HY-169378

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CSI86

CSI86 is a c-MYC PROTAC degrader. CSI86 inhibits the proliferation of various cancer cells and exhibits excellent cellular uptake capacity. CSI86 maintains stability for 72 h in cell culture medium. CSI86 can be used in studies related to breast cancer and prostate cancer.
(Pink: MYC ligand (HY-169379); Blue: VHL ligand (HY-120217); Black: linker (HY-79369)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₄₈H₅₀F₉N₇O₇S
분자량:1040.00

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

CSI86 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

CSI86 is a c-MYC PROTAC degrader. CSI86 inhibits the proliferation of various cancer cells and exhibits excellent cellular uptake capacity. CSI86 maintains stability for 72 h in cell culture medium. CSI86 can be used in studies related to breast cancer and prostate cancer^[1]. (Pink: MYC ligand (HY-169379); Blue: VHL ligand (HY-120217); Black: linker (HY-79369)).

All PROTACs Isoforms :

In Vitro

OthersAnti-cancer

Others

CSI86 (5 μM; 72 h) maintains stability for 72 h in DMEM cell culture medium at 37 °C^[1].
CSI86 (200 μM) directly binds to recombinant bHLH-MYC protein at a concentration of 200 μM^[1].
CSI86 (150 μM; 10 min) does not significantly interfere with the formation of the MYC-MAX complex in recombinant protein pull-down assays^[1].
The cellular uptake rate of CSI86 (10 μM; 24 h) reaches 26% in SKBR3 cells, 19% in PC3 cells, and 10% in A549 cells^[1].

Anti-cancer

CSI86 (10 μM; 24 h) induces c-MYC degradation in PC3 human prostate adenocarcinoma cells^[1].
CSI86 (0.1-100 μM; 72 h) inhibits the growth of SKBR3 human breast cancer cells and PC3 human prostate adenocarcinoma cells, with IC₅₀ values of 15 μM and 18 μM, respectively; it shows no activity against A549 human lung adenocarcinoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

PC3 human prostate adenocarcinoma cells
Concentration:

10 μM
Incubation Time:

24 h
Result:

Reduced c-MYC protein levels relative to untreated control cells.

Related Protocols :

Parmacokinetics

Species	Dose	Route	C_max	AUC_0-24	T_max	T_1/2
Mice^[1]	10 mg/kg	i.p.	713 ng/mL	8.4 μg·h/mL	2 h	7.4 h

Chemical Information

분자량 1040.00
화학식 C₄₈H₅₀F₉N₇O₇S
SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCC(NCCCOC4=C(C(O)=C(C=C4)C5=CC(C(F)(F)F)=NN5C)C6=CC(C(F)(F)F)=CC(C(F)(F)F)=C6)=O)=O)=O)O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Siokatas C, et al. Developing MYC Degraders Bearing the Von Hippel-Lindau Ligand to Target the "Undruggable" MYC. ACS pharmacology & translational science. 2024 Dec 13;7(12):3955-3968. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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