Cyprodinil
Based on 1 Customer Validation
Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens.
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- Purity: 98.84%
- CAS No.: 121552-61-2
- 화학식: C14H15N3
- 분자량:225.29
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Cyprodinil can inhibit the growth of B. cinerea, P. herpotrichoides and H. oryzae in amino acid-free medium, with IC50 values of 0.44, 4.8 and 0.03 µM respectively[1].
Cyprodinil (0.64 nM-50 μM; 24 h) exhibits anti-androgenic activity (IC20: 15.1 μM) in MDA-kb2 cells, and androgenic activity (EC20: 1.91 μM) in the absence of DHT. In addition, it also has certain cytotoxicity[2].
Cyprodinil (0-20 μM; 0-15 h) can increase the protein expression of CYP1A1 in a dose-dependent manner in HO23 and Hepa-1c1c7 cells[3].
Cyprodinil (0-20 μM; 5-20 min) can induce the phosphorylation of ERK1/2 in a variety of cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HO23 and Hepa-1c1c7 cells
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Concentration:0, 1, 5, 10 and 20 μM
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Incubation Time:0, 3, 6, 9, 12 and 15 h
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Result:Increased the protein expression of CYP1A1 in a dose- and time-dependent manner.
Chemical Information
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CAS No. 121552-61-2
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Appearance Solid
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분자량 225.29
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화학식 C14H15N3
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Color White to off-white
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SMILES
CC1=CC(C2CC2)=NC(NC3=CC=CC=C3)=N1
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Synonyms
CGA-219417
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
용액&용해도
DMSO : 100 mg/mL (443.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (11.10 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (273 KB)
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SDS (596 KB)
- English - EN (596 KB)
- Français - FR (596 KB)
- Deutsch - DE (596 KB)
- Norwegian - NO (596 KB)
- Español - ES (596 KB)
- Swedish - SV (596 KB)
- Italian - IT (596 KB)
- Korean - KR (596 KB)
- Portuguese - PT (596 KB)
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Handling Instructions (2659 KB)
References
[2]. Frances Orton, et al. Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens. Environ Health Perspect. 2011 Jun;119(6):794-800. [Content Brief]
[3]. Fang CC, et al. Cyprodinil as an activator of aryl hydrocarbon receptor. Toxicology. 2013 Feb 8;304:32-40. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4387 mL | 22.1936 mL | 44.3872 mL | 110.9681 mL |
| 5 mM | 0.8877 mL | 4.4387 mL | 8.8774 mL | 22.1936 mL | |
| 10 mM | 0.4439 mL | 2.2194 mL | 4.4387 mL | 11.0968 mL | |
| 15 mM | 0.2959 mL | 1.4796 mL | 2.9591 mL | 7.3979 mL | |
| 20 mM | 0.2219 mL | 1.1097 mL | 2.2194 mL | 5.5484 mL | |
| 25 mM | 0.1775 mL | 0.8877 mL | 1.7755 mL | 4.4387 mL | |
| 30 mM | 0.1480 mL | 0.7398 mL | 1.4796 mL | 3.6989 mL | |
| 40 mM | 0.1110 mL | 0.5548 mL | 1.1097 mL | 2.7742 mL | |
| 50 mM | 0.0888 mL | 0.4439 mL | 0.8877 mL | 2.2194 mL | |
| 60 mM | 0.0740 mL | 0.3699 mL | 0.7398 mL | 1.8495 mL | |
| 80 mM | 0.0555 mL | 0.2774 mL | 0.5548 mL | 1.3871 mL | |
| 100 mM | 0.0444 mL | 0.2219 mL | 0.4439 mL | 1.1097 mL |
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