Dehydromiltirone
Based on 1 Customer Validation
Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research.
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- Purity: 99.11%
- CAS No.: 116064-77-8
- 화학식: C19H20O2
- 분자량:280.36
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보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Dehydromiltirone (100 μg/mL; for 24 h) inhibits p38 and NF-κB signaling in Kupffer cells[1].
Dehydromiltirone inhibits the expression of osteoclast-associated genes, including NFATc1, CTSK, c-Fos, Acp5, and MMP9; and the phosphorylation of P38, ERK, and JNK of the MAPK signaling pathway; and the degradation of IκB-α of NF-κB signaling pathway. Dehydromiltirone exhibits an anti-osteoclastogenesis effect by reducing the expression of related genes, ultimately inhibiting bone resorption in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Kupffer cells
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Concentration:100 μg/mL
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Incubation Time:For 24 h
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Result:Significantly decreased p38 and p-p38 levels, NF-κBp65, IκB, and c-fos protein levels.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat model of acute liver injury[1]
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Dosage:50 mg/kg, 100 mg/kg, and 200 mg/kg
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Administration:p.o.; daily; for five consecutive days
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Result:Protected liver from CCl4-induced damage.
Chemical Information
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CAS No. 116064-77-8
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Appearance Solid
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분자량 280.36
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화학식 C19H20O2
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Color Pink to red
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SMILES
O=C1C(C(C)C)=CC2=C(C3=C(C=C2)C(C)(C)CC=C3)C1=O
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Synonyms
1,2-Didehydromiltirone
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
순도&문서
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Shuqiang Yue, et al. Salvia miltiorrhiza compounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells. Pharm Biol. 2014 Oct;52(10):1278-85. [Content Brief]
[2]. Wei Deng, et al. Dehydromiltirone inhibits osteoclast differentiation in RAW264.7 and bone marrow macrophages by modulating MAPK and NF-κB activity. Front Pharmacol. 2022 Sep 21;13:1015693. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dehydromiltirone Related Classifications
HY-122961 Related Classifications
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