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Cat. No.: HY-188147

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EZH2-IN-25

EZH2-IN-25 is an EZH2 inhibitor that inhibits the catalytic subunit of PRC2. EZH2-IN-25 can be used for the research of diffuse large B cell lymphoma.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2636048-41-2
화학식: C₂₅H₃₀ClN₇O₂
분자량:496.00

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

EZH2-IN-25 Chemical Structure

CAS No.: 2636048-41-2

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

EZH2-IN-25 is an EZH2 inhibitor that inhibits the catalytic subunit of PRC2. EZH2-IN-25 can be used for the research of diffuse large B cell lymphoma^[1].

IC₅₀ & Target

^[1]

EZH2

All Histone Methyltransferase Isoforms :

In Vitro

EZH2-IN-25 (example 53) selectively targets EZH2 within the PRC2 pentameric complex, exhibiting a mechanism of inhibition distinct from SAM-competitive inhibitors and EED K27me3-pocket binders^[1].
EZH2-IN-25 selectively targets EZH2 in human cell lines, reducing H3K27me3 levels through a mechanism distinct from SAM-competitive and EED K27me3-pocket binders^[1].
EZH2-IN-25 selectively targets EZH2 and modulates proliferation of human cancer cell lines that depend on PRC2 activity to maintain cancerous growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2636048-41-2
분자량 496.00
화학식 C₂₅H₃₀ClN₇O₂
SMILES

ClC1=NC=CC2=C1N=C(N[C@@H]3CC[C@H](CC3)CNC4=NC=C([C@H](C)C(NC5COC5)=O)C=N4)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Dai X, et al. Inventors; Novartis AG, applicant. WO2021057853A1. 2021 Apr 01.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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EZH2-IN-25

All Histone Methyltransferase Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

EZH2-IN-25 Related Classifications

HY-188147 Related Classifications

Bioz

Keywords

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