Fluorene
Based on 1 publication(s) in Google Scholar
Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders.
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- Purity: 98.07%
- CAS No.: 86-73-7
- 화학식: C13H10
- 분자량:166.22
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보관:
RT, protect from light.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Fluorene
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
>50 μM
Compound: Fluorene
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Cytotoxicity against triple-negative human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Cytotoxicity against triple-negative human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
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[PMID: 32726747] |
Fluorene (200-800 μM, 24-48 hours) induces oxidative stress and inflammation in A549 cells, characterized by increased ROS generation, enhanced lipid peroxidation, altered antioxidant enzyme activity, and upregulated TNF-α and IL-6 expression[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 human lung epithelial cells (lung injury)
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Concentration:200, 400, 600, 800 μM
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Incubation Time:24 hours, 48 hours
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Result:Upregulated TNF-α and IL-6 mRNA and protein expression levels. Additionally, SP-A expression increased in Fluorene-treated groups (400 and 600 μM) but decreased in the PAH mixture-treated group (600 μM).
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Cell Line:A549 human lung epithelial cells (lung injury)
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Concentration:200, 400, 600, 800 μM
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Incubation Time:24 hours, 48 hours
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Result:Induced ROS generation in A549 cells, increased MDA content, and enhanced SOD and CAT activity.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Fluorene oral or intraperitoneal (i.p.) administration-induced body weight and organ changes in Wistar rats[1]
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Dosage:1, 10, 100 mg/kg
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Administration:Oral gavage (p.o.) or intraperitoneal injection (i.p.), once daily for 60 days
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Result:Exhibited significantly reduced weight gain after 28 days and increased relative liver weight (The 100 mg/kg group). Additionally, higher concentrations of Fluorene and its hydroxylated metabolites were detected in the blood and brain of i.p.-treated rats compared to p.o.-treated ones. Reduced anxiety levels in rats (1, 10 mg/kg), while the high dose (100 mg/kg) showed no significant changes. No effects on locomotor activity or learning ability were observed.
Chemical Information
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CAS No. 86-73-7
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Appearance Solid
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분자량 166.22
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화학식 C13H10
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Color White to light brown
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SMILES
C1(C=CC=C2)=C2CC3=C1C=CC=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
RT, protect from light
In solvent -80°C 1 year -20°C 6 months
Publications (1)
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Journal Impact Factor
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Most Recent
용액&용해도
DMSO : 62.5 mg/mL (376.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (283 KB)
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SDS (623 KB)
- English - EN (623 KB)
- Français - FR (623 KB)
- Deutsch - DE (623 KB)
- Norwegian - NO (623 KB)
- Español - ES (623 KB)
- Swedish - SV (623 KB)
- Italian - IT (623 KB)
- Korean - KR (623 KB)
- Portuguese - PT (623 KB)
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Handling Instructions (2659 KB)
References
[1]. Paul Olusegun Bankole, et al. Biodegradation of fluorene by the newly isolated marine-derived fungus, Mucor irregularis strain bpo1 using response surface methodology. Ecotoxicol Environ Saf. 2021 Jan 15;208:111619. [Content Brief]
[2]. Guo H, et al. Oxidative stress and inflammatory effects in human lung epithelial A549 cells induced by phenanthrene, fluorene, and their binary mixture. Environ Toxicol. 2021 Jan;36(1):95-104. [Content Brief]
[3]. Peiffer J, et al. Behavioral toxicity and physiological changes from repeated exposure to fluorene administered orally or intraperitoneally to adult male Wistar rats: A dose–response study[J]. Neurotoxicology, 2016, 53: 321-333. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.0161 mL | 30.0806 mL | 60.1612 mL | 150.4031 mL |
| 5 mM | 1.2032 mL | 6.0161 mL | 12.0322 mL | 30.0806 mL | |
| 10 mM | 0.6016 mL | 3.0081 mL | 6.0161 mL | 15.0403 mL | |
| 15 mM | 0.4011 mL | 2.0054 mL | 4.0107 mL | 10.0269 mL | |
| 20 mM | 0.3008 mL | 1.5040 mL | 3.0081 mL | 7.5202 mL | |
| 25 mM | 0.2406 mL | 1.2032 mL | 2.4064 mL | 6.0161 mL | |
| 30 mM | 0.2005 mL | 1.0027 mL | 2.0054 mL | 5.0134 mL | |
| 40 mM | 0.1504 mL | 0.7520 mL | 1.5040 mL | 3.7601 mL | |
| 50 mM | 0.1203 mL | 0.6016 mL | 1.2032 mL | 3.0081 mL | |
| 60 mM | 0.1003 mL | 0.5013 mL | 1.0027 mL | 2.5067 mL | |
| 80 mM | 0.0752 mL | 0.3760 mL | 0.7520 mL | 1.8800 mL | |
| 100 mM | 0.0602 mL | 0.3008 mL | 0.6016 mL | 1.5040 mL |
Fluorene Related Classifications
HY-W026772 Related Classifications
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