FWG-33B
FWG-33B is an activator of TRMT112:METTL5 complex with an IC50 value of 0.47 μM. FWG-33B can be used for the research of breast carcinoma, hepatocellular carcinoma, nasopharyngeal carcinoma.
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- 화학식: C24H25ClN2O3
- 분자량:424.92
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
FWG-33B (5 μM; 4 hours) engages ~40% of total TRMT112 and >90% of METTL5-complexed TRMT112 in HCT116TRMT112-FLAG:HA-METTL5 cells[1].
FWG-33B (0.01-50 μM; 3 hours pretreatment) stereoselectively engages TRMT112 in HCT116TRMT112-FLAG:HA-METTL5 cells with an IC50 of 1.0 μM[1].
FWG-33B (40 μM; 30 minutes) enhances the methyltransferase activity of WT-TRMT112:METTL5 (but not TRMT112C100A:METTL5) by ~2-fold with 12-nt and 60-nt rRNA substrates[1].
FWG-33B (40 μM; 30 minutes) increases the catalytic efficiency of WT-TRMT112:METTL5 by reducing the Km for rRNA substrate from 10 μM to 4.7 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 424.92
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화학식 C24H25ClN2O3
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SMILES
CC(NC(C=C1)=CC=C1O[C@H]2[C@H]3[C@H](CN(C(C=C)=O)C3)[C@@H](C4=CC(Cl)=CC=C4)C2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FWG-33B Related Classifications
HY-181064 Related Classifications
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