SPN - sialophorin Gene

Also Known as LSN; CD43; GALGP; GPL115; LEU-22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6693

About SPN

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,662,963-29,670,876 (from NCBI)

This gene has 6 transcripts (splice variants) and 82 orthologues. Biased expression in bone marrow (RPKM 10.2), lymph node (RPKM 6.8) and 13 other tissues.

Summary

This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017]

SPN Products (2)

mRNA	Protein	Name
NM_001030288.4	NP_001025459.1	leukosialin precursor
NM_003123.6	NP_003114.1	leukosialin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	20633027	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	20633027	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T-helper 1 cell lineage commitment	IDA IDA: Inferred from direct assay	18036228	GOA
acts upstream of or within defense response to bacterium	IDA IDA: Inferred from direct assay	10899905	GOA
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	10899905	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	12354383	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	10899905	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
leukosialin	galactoglycoprotein

SPN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SPN	P16150	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	SPN	P16150	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	SPN	P16150	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	SPN	P16150	PPGB	Homo sapiens	Q59EV6	Validated Y2H	32296183
Intra	SPN	P16150	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	SPN	P16150	SGTA	Homo sapiens	O43765	Validated Y2H	32296183
Intra	SPN	P16150	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	SPN	P16150	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	SPN	P16150	PLP2	Homo sapiens	Q04941	Validated Y2H	32296183
Intra	SPN	P16150	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	SPN	P16150	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	SPN	P16150	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	SPN	P16150	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	SPN	P16150	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	SPN	P16150	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPN Proteins

Cat. No.	상품명	Accession	Purity
HY-P77887	CD43 Protein, Human (HEK293, His)	P16150 (S20-R253)	≥ 95%, as determined by Bis-Tris PAGE.

SPN Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P80061	CD43 Antibody (YA802)	WB, IHC-P, FC	Human
HY-P84125	CD43 Antibody (YA3822)	WB, IHC-P, FC, ELISA	Human
HY-P84125A	CD43 Antibody (YA3822)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P86380	CD43 Antibody (YA6072)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Aleukemic Monocytic Leukemia Cutis
Multicentric Papillary Thyroid Carcinoma	Multicentric Thyroid Gland Papillary Carcinoma
Chronic Inflammation Of Lacrimal Passage
Dacryocystocele	Lacrimal Mucocele
Mu Chain Disease	Mu-Chain Disease
Bladder Lymphoma	Lymphoma Of The Urinary Bladder
Aleukemic Leukemia Cutis
Myeloid Sarcoma	Granulocytic Sarcoma Chloroma Extramedullary Myeloid Tumor Sarcoma, Granulocytic Sarcoma Granulocytic Sarcoma, Myeloid Myelosarcoma Myeloid Sarcoma Disease Myeloid Sarcoma Nos Myeloid Sarcoma Without Mention Of Remission
Hodgkin'S Lymphoma, Mixed Cellularity	Hodgkin'S Disease, Mixed Cellularity Hodgkins Lymphoma, Mixed Cellularity Mixed Cellularity Hodgkin Lymphoma
Esophagus Lymphoma	Lymphoma Of Esophagus Lymphoma Of Oesophagus Oesophagus Lymphoma Esophageal Lymphoma
Bone Lymphoma	Lymphoma Of Bone Lymphoma Of The Bone
Nodular Episcleritis
Lung Lymphoma	Pulmonary Lymphoma Lymphoma Of Lung Primary Lung Lymphoma
Ostertagiasis
Marginal Zone B-Cell Lymphoma	Marginal Zone Lymphoma Mzl Mucosa-Associated Lymphoid Tissue Lymphoma
Lethal Midline Granuloma	Granuloma, Lethal Midline Malignant Granuloma Of Face Midfacial Necrotising Lesion Midline Lethal Granuloma
Breast Lymphoma	Lymphoma Of Breast Lymphoma Of The Breast Malignant Lymphoma Of Breast
Gastrointestinal Lymphoma
Nodal Marginal Zone Lymphoma	Mucosa-Associated Lymphoid Tissue Lymphoma Monocytoid B-Cell Lymphoma
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma	Cll/Sll B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma Icdo:9823/3 Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission Small Cell B-Cell Lymphoma
Spleen Cancer	Spleen Neoplasm Splenic Neoplasm Splenic Neoplasms Malignant Splenic Tumor Malignant Tumour Of Spleen Tumor Of Spleen Malignant Neoplasm Of Spleen
Splenic Marginal Zone Lymphoma	Smzl Splenic Marginal Zone B-Cell Lymphoma
Composite Lymphoma	Composite Hodgkin And Non-Hodgkin Lymphoma
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Ureteral Lymphoma	Lymphoma Of Ureter Ureter Lymphoma
Gastric Lymphoma	Familial Primary Gastric Lymphoma Lymphoma Of The Stomach Primary Gastric Lymphoma
Epithelioid Cell Synovial Sarcoma	Synovial Sarcoma, Epithelioid Cell Epithelioid Synovial Sarcoma
Lymphoplasmacytic Lymphoma	Waldenstrom Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic Waldenström Macroglobulinaemia Waldenström Macroglobulinaemia Without Mention Of Remission Idiopathic Macroglobulinaemia Primary Macroglobulinaemia
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Infected Hydrocele	Pyocele
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Renal Pelvis Transitional Cell Carcinoma	Urothelial Cell Carcinoma Of Renal Pelvis Renal Pelvis Urothelial Carcinoma Transitional Cell Carcinoma Of Renal Pelvis
Mature T-Cell And Nk-Cell Lymphoma	Mature T-Cell And Natural Killer Cell Lymphoma Nk-T Cell Lymphoma
Mature B-Cell Neoplasm	Mature B-Cell Lymphocytic Neoplasm Neoplasm Of Mature B-Cells Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour
Hemoglobin H Disease	HBH Hemoglobin H Disease, Nondeletional Hemoglobin H Disease, Deletional Alpha-Thalassemia Intermedia Haemoglobin H Disease Alpha-Thalassemia, Hemoglobin H Type Hemoglobin H Disease, Deletional And Nondeletional Alpha Thalassemia, Haemoglobin H Type Alpha Thalassemia, Hemoglobin H Type Haemoglobin H Disease, Deletional Hbh Disease Alpha-Thalassemia Hemoglobin H Type Hemoglobin H Disease Deletional Hemoglobin H Disease Non-Deletional Alpha-Thalassemia Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia Alpha Thalassaemia Intermedia
Appendix Lymphoma	Appendiceal Lymphoma
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-107434	Molindone	Antagonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-149004	SLF1081851	Inhibitor	98.02%	Unkown
HY-P0242A	Neurokinin B TFA	Agonist	99.36%	Unkown
HY-162655	SLF80821178	Inhibitor	99.70%	Unkown
HY-150254A	SLB1122168 formic	Inhibitor	99.91%	Unkown
HY-150254	SLB1122168	Inhibitor	/	Unkown
HY-149004A	SLF1081851 TFA	Inhibitor	/	Unkown
HY-149004B	SLF1081851 hydrochloride		/	Unkown
HY-156408	Spns2-IN-1	Inhibitor	/	Unkown
HY-162655A	SLF80821178 hydrochloride	Inhibitor	/	Unkown
HY-162996	Spns2-IN-2	Inhibitor	/	Unkown
HY-182375	(R)-SLB1122168 free base	Inhibitor	/	Unkown
HY-182375A	SLB1122168 free base	Inhibitor	/	Unkown
HY-182456	CHDI-340246	Inhibitor	/	Unkown
HY-P10312	SPN009	Agonist	/	Unkown
HY-RS03666	DEAF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11006	PPP1R9B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13689	SPN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13690	SPNS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13691	SPNS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13692	SPNS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-107434S	Molindone-d8	Inhibitor	99.49%	Unkown
HY-RS18595	Spn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19483	Spns2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25080	Spn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25976	Spns2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPN	VGNC	VGNC:35224
Rattus norvegicus	SPN	RGD	RGD:3750
Macaca mulatta	SPN	VGNC	VGNC:77861
Canis familiaris	SPN	VGNC	VGNC:58334
Mus musculus	SPN	MGD	MGI:98384
Others	SPN	NCBI