Gentamicin C1a
Based on 1 Customer Validation
Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex.
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- Purity : 98.0%
- CAS No.: 26098-04-4
- 화학식: C19H39N5O7
- 분자량:449.54
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
>300 μM
Compound: Gentamicin
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Cytotoxicity against HEK293 cells after 24 hrs by resazurin assay
Cytotoxicity against HEK293 cells after 24 hrs by resazurin assay
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[PMID: 26734854] |
| HepG2 | CC50 |
>300 μM
Compound: Gentamicin
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Cytotoxicity against human HepG2 cells after 24 hrs by resazurin assay
Cytotoxicity against human HepG2 cells after 24 hrs by resazurin assay
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[PMID: 26734854] |
| HK-2 | CC50 |
33 μg/mL
Compound: Gentamicin
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Cytotoxicity against HK2 cells assessed as GGT release by Western blot analysis
Cytotoxicity against HK2 cells assessed as GGT release by Western blot analysis
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[PMID: 26734854] |
| HK-2 | CC50 |
33 μg/mL
Compound: Gentamicin
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Cytotoxicity against HK2 cells assessed as LDH release by Western blot analysis
Cytotoxicity against HK2 cells assessed as LDH release by Western blot analysis
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[PMID: 26734854] |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 26098-04-4
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Appearance Solid
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분자량 449.54
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화학식 C19H39N5O7
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Color White to light yellow
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SMILES
O[C@@H]([C@@H]([C@H](C[C@H]1N)N)O[C@H]2O[C@@H](CC[C@H]2N)CN)[C@H]1O[C@@H]3[C@@H]([C@H]([C@@](O)(CO3)C)NC)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
In Vitro:
H2O : 100 mg/mL (222.45 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (284 KB)
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SDS (585 KB)
- English - EN (585 KB)
- Français - FR (585 KB)
- Deutsch - DE (585 KB)
- Norwegian - NO (585 KB)
- Español - ES (585 KB)
- Swedish - SV (585 KB)
- Italian - IT (585 KB)
- Korean - KR (585 KB)
- Portuguese - PT (585 KB)
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Handling Instructions (2659 KB)
References
[1]. Li D, et al. Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. Microbiol Res. 2013 Jun 12;168(5):263-7. [Content Brief]
[2]. Ishikawa M, et al. Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use. Sci Rep. 2019 Feb 20;9(1):2410. [Content Brief]
[3]. Isoherranen N, et al. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose. Antimicrob Agents Chemother. 2000 Jun;44(6):1443-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.2245 mL | 11.1225 mL | 22.2450 mL | 55.6124 mL |
| 5 mM | 0.4449 mL | 2.2245 mL | 4.4490 mL | 11.1225 mL | |
| 10 mM | 0.2224 mL | 1.1122 mL | 2.2245 mL | 5.5612 mL | |
| 15 mM | 0.1483 mL | 0.7415 mL | 1.4830 mL | 3.7075 mL | |
| 20 mM | 0.1112 mL | 0.5561 mL | 1.1122 mL | 2.7806 mL | |
| 25 mM | 0.0890 mL | 0.4449 mL | 0.8898 mL | 2.2245 mL | |
| 30 mM | 0.0741 mL | 0.3707 mL | 0.7415 mL | 1.8537 mL | |
| 40 mM | 0.0556 mL | 0.2781 mL | 0.5561 mL | 1.3903 mL | |
| 50 mM | 0.0445 mL | 0.2224 mL | 0.4449 mL | 1.1122 mL | |
| 60 mM | 0.0371 mL | 0.1854 mL | 0.3707 mL | 0.9269 mL | |
| 80 mM | 0.0278 mL | 0.1390 mL | 0.2781 mL | 0.6952 mL | |
| 100 mM | 0.0222 mL | 0.1112 mL | 0.2224 mL | 0.5561 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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