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Cat. No.: HY-18203

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HBF-0079

HBF-0079 is a selective anti-hepatocellular carcinoma agent. HBF-0079 induces cell cycle arrest and Apoptosis. HBF-0079 modulates cell-growth and anti-apoptotic signaling through AKT and mTOR. HBF-0079 exhibits antitumor activity against hepatocellular carcinoma.

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CAS No.: 315702-93-3
화학식: C₁₂H₉N₅S
분자량:255.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

HBF-0079 Chemical Structure

CAS No.: 315702-93-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Akt Isoforms :

All mTOR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>30 μM Compound: 10	Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay	[PMID: 18774291]
Huh-7	CC₅₀	1.1 μM Compound: HBF-0079	Cytotoxicity against human HuH7 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HuH7 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 27793566]

Chemical Information

CAS No. 315702-93-3
분자량 255.30
화학식 C₁₂H₉N₅S
SMILES

C1(C2=CSC(NC3=NC=CC=N3)=N2)=NC=CC=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cuconati A, et al. Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells. PLoS One. 2013;8(1):e54595. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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수량:
MCE Japan Authorized Agent:

상품명:
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HBF-0079

All Akt Isoforms

All mTOR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HBF-0079 Related Classifications

HY-18203 Related Classifications