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Cat. No.: HY-129094

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ICT5040

ICT5040 is a small molecule CXCR4 antagonist (IC₅₀=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells.

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CAS No.: 215655-21-3
화학식: C₁₀H₈F₃N₃OS
분자량:275.25

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ICT5040 Chemical Structure

CAS No.: 215655-21-3

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

CXCR4

3.8 μM (IC₅₀)

All CXCR Isoforms :

In Vitro

ICT5040 (1-100 μM; 0-4 d) dose-dependently inhibits CXCL12-induced proliferation and migration of U87-glioma cells^[1].
ICT5040 reduces CXCL12-induced intracellular calcium mobilisation in U87 glioma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

U87-glioma cells
Concentration:

1 μM, 10 μM, 100 μM; with 100 ng/mL CXCL12
Incubation Time:

0, 1, 2, 3, and 4 days
Result:

Resulted reduction of CXCL12 induced proliferation and migration of U87 cells at day 3.

Chemical Information

CAS No. 215655-21-3
분자량 275.25
화학식 C₁₀H₈F₃N₃OS
SMILES

FC(C1=CC=C(C2=NN=C(SC)O2)C(C)=N1)(F)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vinader V, et al. Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists. PLoS One. 2013 Oct 18;8(10):e78744. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

ICT5040

All CXCR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ICT5040 Related Classifications

HY-129094 Related Classifications