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Cat. No.: HY-182749

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KRAS-IN-58

KRAS-IN-58 is a KRAS inhibitor with a IC₅₀ of 0.223 μM against KRAS^G12D. KRAS-IN-58 binds to KRAS^G12C and KRAS^G12D proteins, and reduces the levels of phosphorylated Raf1, AKT and ERK in pancreatic cancer cells. KRAS-IN-58 can be used for the research of pancreatic cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₁H₁₇N₅O₃S₂
분자량:451.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS-IN-58 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

KRas G12D

223 nM (IC₅₀)

All Ras Isoforms :

All Akt Isoforms :

All Raf Isoforms :

All ERK Isoforms :

In Vitro

KRAS-IN-58 (Compound 10b) (24 h) inhibits viability of ASPC-1, PANC-1, and Miapac-2 pancreatic cancer cells with IC₅₀ values of 1.16 μM, 6.59 μM, and 6.432 μM, respectively^[1].
KRAS-IN-58 (24 h) inhibits viability of SW1990 pancreatic cancer cells with an IC₅₀ of 1.518 μM, while showing much weaker activity against LO2 normal hepatic cells (IC₅₀ = 55.53 μM) and HPDE6-C7 normal pancreatic epithelial cells (IC₅₀ = 10.50 μM), demonstrating selective activity for cancerous over non-cancerous cells^[1].
pan-KRAS-IN-19 (1.25-20 μM) dose-dependently downregulates levels of KRAS, pRaf1, pAKT, and pERK in ASPC-1 and Miapac-2 pancreatic cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	MRT	CL	V_ss	V_z	AUC
Mice^[1]	2 mg/kg	i.v.	4.3 h	/	/	0.512 h	66 mL/min/kg	2.6 L/kg	26 L/kg	510 ng·h/mL
Mice^[1]	10 mg/kg	p.o.	6.52 h	0.333 h	1.4 ng/mL	2.82 h	/	/	/	/

Chemical Information

분자량 451.52
화학식 C₂₁H₁₇N₅O₃S₂
SMILES

CN1C=CC=C1/C=C2SC(N(C\2=O)CCSC3=NN=C(O3)C4=CNC5=C4C=CC=C5)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhang P, et al. Active fragment assembly strategy enabling fast discovery of KRAS inhibitors against pancreatic cancer cells. Eur J Med Chem. 2026;310:118807. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

KRAS-IN-58

All Ras Isoforms

All Akt Isoforms

All Raf Isoforms

All ERK Isoforms