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Cat. No.: HY-178956

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KUNB106

KUNB106 is a selective Hsp90β inhibitor with K_Ds of 91 nM and 38 μM against Hsp90β and Hsp90α. KUNB106 exhibits antiproliferative activity against MDA-MB-231 cells, A549 and SKOV-3 cells. KUNB106 can be used for the study of triple negative breast cancer.

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CAS No.: 2393980-27-1
화학식: C₂₇H₃₄N₄O₃
분자량:462.58

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

KUNB106 Chemical Structure

CAS No.: 2393980-27-1

사이즈

가격

재고

수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

HSP90β

91 nM (Kd)

HSP90α

38 μM (Kd)

All HSP Isoforms :

Chemical Information

CAS No. 2393980-27-1
분자량 462.58
화학식 C₂₇H₃₄N₄O₃
SMILES

CCCC1=CC2=C(C(N3CCC(CC3)O)=CC(N4N=C(C5=C4CC(C)(CC5=O)C)C)=C2)C(N1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Serwetnyk MA, et al. Optimization of an Hsp90β-selective inhibitor via exploration of the Hsp90 N-terminal ATP-binding pocket. Eur J Med Chem. 2025 Nov 5;297:117925. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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수량:
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KUNB106

All HSP Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

KUNB106 Related Classifications

HY-178956 Related Classifications