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Cat. No.: HY-105933

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L-652343

L-652343 is a dual cyclooxygenase/lipoxygenase inhibitor. L-652343 can inhibit the production of LTB₄ in isolated human polymorphonuclear leukocytes treated with Calcimycin (HY-N6687) (IC₅₀: 1.4 μM), but it is inactive in whole blood. L-652343 can be used in the research of inflammatory and immune diseases.

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CAS No.: 107008-29-7
화학식: C₂₂H₁₄F₃NO₂S₂
분자량:445.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

L-652343 Chemical Structure

CAS No.: 107008-29-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

LTB₄

All Lipoxygenase Isoforms :

All COX Isoforms :

All Leukotriene Receptor Isoforms :

Chemical Information

CAS No. 107008-29-7
분자량 445.48
화학식 C₂₂H₁₄F₃NO₂S₂
SMILES

OC1=C(C(N/C=C(C2=CC=CC=C2)/C3=CC=CS3)=O)SC4=C1C=C(C(F)(F)F)C=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gresele P, et al. L-652,343, a novel dual cyclo/lipoxygenase inhibitor, inhibits LTB4-production by stimulated human polymorphonuclear cells but not by stimulated human whole blood. Biochem Pharmacol. 1987 Oct 15;36(20):3529-31. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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L-652343

All Lipoxygenase Isoforms

All COX Isoforms

All Leukotriene Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

L-652343 Related Classifications

HY-105933 Related Classifications