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Cat. No.: HY-129396

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LA1011

LA1011 is a heat shock protein (Hsps) co-inducer that selectively enhances heat shock-induced Hsp70, Hsp40, and Hsp27 expression. LA1011 exhibits neuroprotective effects in APPxPS1 transgenic Alzheimer's disease mice, preventing hippocampal neuronal loss, reducing tau pathology and neurofibrillary tangle accumulation in the hippocampus, decreasing amyloid plaque formation in the hippocampus, and increasing dendritic spine density in hippocampal CA1. LA1011 can be used for research on Alzheimer's disease.

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CAS No.: 1439268-65-1
화학식: C₂₅H₃₆Cl₂F₃N₃O₄
분자량:570.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

LA1011 Chemical Structure

CAS No.: 1439268-65-1

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

HSP70

HSP40

All HSP Isoforms :

In Vitro

LA1011 (5-10 µM) does not alter yeast Hsp90 ATPase activity^[1].
LA1011 (5 µM; 30 min-17 h) co-induced Hsp70 promoter-driven YFP expression in SH-SY5Y-pHsp70-YFP cells under 42°C heat shock conditions^[1].
LA1011 (5 µM; 1-16 h) selectively co-induces Hsp27, Hsp40, and Hsp70 in heat-shocked SH-SY5Y cells without altering Hsp levels under non-stressed conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

SH-SY5Y cells
Concentration:

5 µM
Incubation Time:

1 h (42°C heat shock); 16 h (37°C recovery)
Result:

Increased Hsp27, Hsp40, and Hsp70 levels under heat shock.
Did not alter Hsp27, Hsp40, Hsp70, Hsp60, or Hsp90 levels without heat shock.

In Vivo

LA1011 (3 mg/kg; i.p.; once daily; 6 months) has neuroprotective effects in APPxPS1 transgenic AD mice, improving spatial learning and reducing neuronal loss, tau pathology, dendritic spine loss, and amyloid plaque formation; it also improves spatial memory performance in healthy wild-type mice without altering dendritic spine density^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

B6C3-Tg (APPswe/PS1dE9)85Dbo/Mmjax (C57BL/6 genetic background; male; 3 months old at start)^[1]
Dosage:

3 mg/kg
Administration:

i.p.; once daily; 6 months
Result:

Improved spatial learning and memory in the Morris water maze.
Required less time to find the platform than transgenic saline controls.
Prevented loss of hippocampal neurons.
Decreased the number of abnormally accumulated neurofibrillary tangles in the hippocampus to the level found in wild-type mice.
Increased dendritic spine number in hippocampal CA1 compared with transgenic saline controls.
Decreased amyloid plaque formation in the hippocampus.

Animal Model:

wild-type C57BL/6 (male; 3 months old at start)^[1]
Dosage:

3 mg/kg
Administration:

i.p.; once daily; 6 months
Result:

Improved memory performance in the Morris water maze.
Required less time to complete the task than wild-type saline controls.
Did not affect dendritic spine number in wild-type mice.

Related Protocols :

Chemical Information

CAS No. 1439268-65-1
분자량 570.47
화학식 C₂₅H₃₆Cl₂F₃N₃O₄
SMILES

O=C(C1=C(CCN(C)C)N(C)C(CCN(C)C)=C(C1C2=CC=C(C(F)(F)F)C=C2)C(OC)=O)OC.Cl.Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kasza Á, et al. Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2016 May 07;53(2):557-71.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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