(-)BI97D6
(-)BI97D6 is a broad-spectrum inhibitor of the Bcl-2 protein family, inhibiting Mcl-1, Bcl-2, Bcl-xL and Bcl-1 with IC50 values of 0.025, 0.031, 0.076 and 0.122 μM, respectively. (-)BI97D6 stimulates cell death through the Bak and Bax mediated mitochondrial apoptosis pathway. In addition, (-)BI97D6 inhibits Mcl-1 and can effectively induce apoptosis in acute myeloid leukemia (AML) cells.
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- CAS No.: 1430067-36-9
- 화학식: C36H26O8
- 분자량:586.59
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
Bcl-xL 0.076 μM (IC50) |
Mcl-1 0.025 μM (IC50) |
Bcl-2 0.031 μM (IC50) |
Bcl-1 0.122 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H1299 | EC50 |
0.31 μM
Compound: 6i
|
Cytotoxicity against human H1299 cells expressing high level of Mcl-1 after 72 hrs by ATP-LITE assay
Cytotoxicity against human H1299 cells expressing high level of Mcl-1 after 72 hrs by ATP-LITE assay
|
[PMID: 21033669] |
| NCI-H460 | EC50 |
0.13 μM
Compound: 6i
|
Cytotoxicity against human H460 cells expressing high level of Bcl-2 after 72 hrs by ATP-LITE assay
Cytotoxicity against human H460 cells expressing high level of Bcl-2 after 72 hrs by ATP-LITE assay
|
[PMID: 21033669] |
| PC-3 | EC50 |
0.59 μM
Compound: 6i
|
Cytotoxicity against human PC3 cells expressing high level of Bcl-xL after 72 hrs by ATP-LITE assay
Cytotoxicity against human PC3 cells expressing high level of Bcl-xL after 72 hrs by ATP-LITE assay
|
[PMID: 21033669] |
| RS4-11 | EC50 |
6.9 μM
Compound: 6i
|
Cytotoxicity against human RS4:11 cells expressing high level of Bcl-2 and Bcl-xL after 72 hrs by annexin V-FITC and propidium iodide staining
Cytotoxicity against human RS4:11 cells expressing high level of Bcl-2 and Bcl-xL after 72 hrs by annexin V-FITC and propidium iodide staining
|
[PMID: 21033669] |
Chemical Information
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CAS No. 1430067-36-9
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분자량 586.59
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화학식 C36H26O8
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SMILES
O=C1C2=CC(O)=C(C(CC3=CC=CC=C3)=C2C(C(C)=C1C(C(C4=CC(O)=C(C(CC5=CC=CC=C5)=C46)O)=O)=C(C)C6=O)=O)O
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선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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