Cat. No.: HY-107939

Paramethasone Acetate

고객리뷰

Based on 1 Customer Validation

Paramethasone Acetate is an orally active long-acting glucocorticoid. Paramethasone Acetate directly inhibits testicular aromatase, thereby reducing the synthesis of estradiol. Paramethasone Acetate suppresses the basal and midcycle luteinizing hormone surges in female animals and blocks estrogen synthesis. Paramethasone Acetate also decreases circulating levels of dihydrotestosterone, androstenedione and estradiol in male animals. Paramethasone Acetate inhibits cartilage degeneration and alleviates joint pathological damage in osteoarthritis models. Paramethasone Acetate can be used in research related to osteoarthritis and endocrinology.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.0%
CAS No.: 1597-82-6
화학식: C₂₄H₃₁FO₆
분자량:434.50

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Paramethasone Acetate Chemical Structure

CAS No.: 1597-82-6

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Cytochrome P450 Isoforms :

In Vivo

Paramethasone Acetate (0.1 mg/kg; i.g.; 5 days per week; 5 weeks) significantly reduces the severity of surgically induced osteoarthritis in male New Zealand white rabbits^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

New Zealand white (male, ~4 kg, surgically induced model)^[2]
Dosage:

0.1 mg/kg
Administration:

p.o.; 5 days per week; 5 weeks
Result:

Reduced global lesion scores for tibial and femoral cartilage significantly relative to controls.
Maintained cartilage architecture.
Partially prevented chondrocyte loss and stainable proteoglycan loss.
Markedly reduced the incidence and severity of osteophytes.
Reduced the size and number of chondrocyte clones.
Lowered the incidence and severity of ulcers and fissures.

Chemical Information

CAS No. 1597-82-6
Appearance Solid
분자량 434.50
화학식 C₂₄H₃₁FO₆
Color White to light yellow
SMILES

C[C@@]12[C@](C[C@H]([C@]2(O)C(COC(C)=O)=O)C)([H])[C@@]3([H])[C@]([C@@]4(C([C@H](C3)F)=CC(C=C4)=O)C)([H])[C@H](C1)O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : ≥ 125 mg/mL (287.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3015 mL

11.5075 mL

23.0150 mL

5 mM

0.4603 mL

2.3015 mL

4.6030 mL

10 mM

0.2301 mL

1.1507 mL

2.3015 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cortés-Gallegos V, et al. Paramethasone acetate (PA): corticosteroid potency vs hypothalamic pituitary-gonadal axis. J Steroid Biochem. 1984;20(1):353-356. [Content Brief]

[2]. Colombo C, et al. A new model of osteoarthritis in rabbits. II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemically. Arthritis Rheum. 1983 Sep;26(9):1132-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3015 mL	11.5075 mL	23.0150 mL	57.5374 mL
	5 mM	0.4603 mL	2.3015 mL	4.6030 mL	11.5075 mL
	10 mM	0.2301 mL	1.1507 mL	2.3015 mL	5.7537 mL
	15 mM	0.1534 mL	0.7672 mL	1.5343 mL	3.8358 mL
	20 mM	0.1151 mL	0.5754 mL	1.1507 mL	2.8769 mL
	25 mM	0.0921 mL	0.4603 mL	0.9206 mL	2.3015 mL
	30 mM	0.0767 mL	0.3836 mL	0.7672 mL	1.9179 mL
	40 mM	0.0575 mL	0.2877 mL	0.5754 mL	1.4384 mL
	50 mM	0.0460 mL	0.2301 mL	0.4603 mL	1.1507 mL
	60 mM	0.0384 mL	0.1918 mL	0.3836 mL	0.9590 mL
	80 mM	0.0288 mL	0.1438 mL	0.2877 mL	0.7192 mL
	100 mM	0.0230 mL	0.1151 mL	0.2301 mL	0.5754 mL

Keywords

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Paramethasone Acetate

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

FDA-Approved Drug Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Antioxidant Compound Library

Lipid Compound Library

Oxygen Sensing Compound Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Mitochondria-Targeted Compound Library

Protein-protein Interaction Inhibitor Library

Human Metabolite Library

Nuclear Receptor Compound Library

Pain-Related Compound Library

Off-patent Drug Library

Metabolic Enzyme Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Human Hormone Compound Library

Mass Spectrometry Human Metabolite Library

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Paramethasone Acetate

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

FDA-Approved Drug Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Antioxidant Compound Library

Lipid Compound Library

Oxygen Sensing Compound Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Mitochondria-Targeted Compound Library

Protein-protein Interaction Inhibitor Library

Human Metabolite Library

Nuclear Receptor Compound Library

Pain-Related Compound Library

Off-patent Drug Library

Metabolic Enzyme Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Human Hormone Compound Library

Mass Spectrometry Human Metabolite Library

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Paramethasone Acetate Related Classifications

HY-107939 Related Classifications