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Cat. No.: HY-N16719

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Picrasidine J

Picrasidine J is a selective inhibitor targeting the KLK-10 protease and the ERK signaling pathway. Picrasidine J inhibits epithelial-mesenchymal transition (EMT) by upregulating E-Cadherin and ZO-1 and downregulating β-catenin and Snail, while simultaneously reducing KLK-10 expression and inhibiting ERK phosphorylation, thereby exhibiting significant anti-migratory and anti-invasive activity. Picrasidine J can inhibit the metastasis of head and neck squamous cell carcinoma (HNSCC) and is primarily used in anti-metastasis research for head and neck tumors.

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CAS No.: 100234-62-6
화학식: C₁₄H₁₄N₂O₂
분자량:242.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Picrasidine J Chemical Structure

CAS No.: 100234-62-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

KLK10

E-cadherin (CDH1)

All Kallikrein Isoforms :

All ERK Isoforms :

Chemical Information

CAS No. 100234-62-6
분자량 242.27
화학식 C₁₄H₁₄N₂O₂
SMILES

OC1=CC=CC2=C1NC3=C2C(OC)=CN=C3CC
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. OHMOTO T, et al. Studies on the alkaloids from Picrasma quassioides bennet. VI. Structures of picrasidines N, O, and Q[J]. Chemical and pharmaceutical bulletin, 1985, 33(11): 4901-4905.

[2]. Ho HY, et al. Picrasidine J, a Dimeric β-Carboline-Type Alkaloid from Picrasma quassioides, Inhibits Metastasis of Head and Neck Squamous Cell Carcinoma. Int J Mol Sci. 2023 Aug 25;24(17):13230. [Content Brief]

Calculators

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Mass Mass

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Volume Volume

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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Picrasidine J

All Kallikrein Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Picrasidine J Related Classifications

HY-N16719 Related Classifications