N-Methylated pomalidomide
Based on 1 Customer Validation
N-methylated pomalidomide (Pomalidomide-methyl), a derivative of Pomalidomide (HY-10984), is a cereblon (CRBN) ligand. N-methylated pomalidomide is unable to recruit CRBN that can be used as a negative control for Pomalidomide. N-methylated pomalidomide can be used to synthesize PROTAC.
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- Purity: 98.82%
- CAS No.: 1352827-50-9
- 화학식: C14H13N3O4
- 분자량:287.27
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1352827-50-9
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Appearance Solid
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분자량 287.27
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화학식 C14H13N3O4
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Color Light yellow to yellow
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SMILES
O=C1C2=C(C(N1C3C(N(C)C(CC3)=O)=O)=O)C(N)=CC=C2
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Synonyms
Pomalidomide-methyl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : 100 mg/mL (348.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4810 mL | 17.4052 mL | 34.8105 mL | 87.0261 mL |
| 5 mM | 0.6962 mL | 3.4810 mL | 6.9621 mL | 17.4052 mL | |
| 10 mM | 0.3481 mL | 1.7405 mL | 3.4810 mL | 8.7026 mL | |
| 15 mM | 0.2321 mL | 1.1603 mL | 2.3207 mL | 5.8017 mL | |
| 20 mM | 0.1741 mL | 0.8703 mL | 1.7405 mL | 4.3513 mL | |
| 25 mM | 0.1392 mL | 0.6962 mL | 1.3924 mL | 3.4810 mL | |
| 30 mM | 0.1160 mL | 0.5802 mL | 1.1603 mL | 2.9009 mL | |
| 40 mM | 0.0870 mL | 0.4351 mL | 0.8703 mL | 2.1757 mL | |
| 50 mM | 0.0696 mL | 0.3481 mL | 0.6962 mL | 1.7405 mL | |
| 60 mM | 0.0580 mL | 0.2901 mL | 0.5802 mL | 1.4504 mL | |
| 80 mM | 0.0435 mL | 0.2176 mL | 0.4351 mL | 1.0878 mL | |
| 100 mM | 0.0348 mL | 0.1741 mL | 0.3481 mL | 0.8703 mL |
N-Methylated pomalidomide Related Classifications
HY-W586822 Related Classifications
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