PRMT5-IN-31
Based on 1 Customer Validation
PRMT5-IN-31 (Compound 3m) is a selective PRMT5 inhibitor (IC50: 0.31 μM). PRMT5-IN-31 up-regulates hnRNP E1 protein level. PRMT5-IN-31 occupies the substrate site of PRMT5 and forms essential interactions with amino acid residues. PRMT5-IN-31 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. PRMT5-IN-31 has high metabolic stability on human liver microsomes (T1/2: 132.4 min).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.25%
- 화학식: C21H24N2O2
- 분자량:336.43
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보관:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
제품 설명
IC50 & Target
0.31 μM (PRMT5)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
19.13 μM
Compound: 3m
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Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
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[PMID: 37429083] |
| HepG2 | IC50 |
27.69 μM
Compound: 3m
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
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[PMID: 37429083] |
| L02 | IC50 |
>100 μM
Compound: 3m
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Antiproliferative activity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Antiproliferative activity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
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[PMID: 37429083] |
| MCF7 | IC50 |
23.63 μM
Compound: 3m
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
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[PMID: 37429083] |
| MDA-MB-231 | IC50 |
20.51 μM
Compound: 3m
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
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[PMID: 37429083] |
Chemical Information
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Appearance Solid
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분자량 336.43
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화학식 C21H24N2O2
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Color Off-white to light yellow
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SMILES
O[C@@H](CN1C=CC2=C1C=CC(OC)=C2)CN(C3)CCC4=C3C=CC=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
용액&용해도
In Vitro:
DMSO : 50 mg/mL (148.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9724 mL | 14.8619 mL | 29.7239 mL | 74.3097 mL |
| 5 mM | 0.5945 mL | 2.9724 mL | 5.9448 mL | 14.8619 mL | |
| 10 mM | 0.2972 mL | 1.4862 mL | 2.9724 mL | 7.4310 mL | |
| 15 mM | 0.1982 mL | 0.9908 mL | 1.9816 mL | 4.9540 mL | |
| 20 mM | 0.1486 mL | 0.7431 mL | 1.4862 mL | 3.7155 mL | |
| 25 mM | 0.1189 mL | 0.5945 mL | 1.1890 mL | 2.9724 mL | |
| 30 mM | 0.0991 mL | 0.4954 mL | 0.9908 mL | 2.4770 mL | |
| 40 mM | 0.0743 mL | 0.3715 mL | 0.7431 mL | 1.8577 mL | |
| 50 mM | 0.0594 mL | 0.2972 mL | 0.5945 mL | 1.4862 mL | |
| 60 mM | 0.0495 mL | 0.2477 mL | 0.4954 mL | 1.2385 mL | |
| 80 mM | 0.0372 mL | 0.1858 mL | 0.3715 mL | 0.9289 mL | |
| 100 mM | 0.0297 mL | 0.1486 mL | 0.2972 mL | 0.7431 mL |
PRMT5-IN-31 Related Classifications
HY-155050 Related Classifications
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