REV 5901
Based on 1 Customer Validation
REV 5901 is a competitive and orally active antagonist of leukotriene receptor, with a Ki of 0.7 μM. REV 5901 is also a 5-lipoxygenase inhibitor. REV 5901 can be used for the research of asthma in which leukotriene release be involved. REV 5901 can be used for the study of colon carcinoma.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.9%
- CAS No.: 101910-24-1
- 화학식: C22H25NO2
- 분자량:335.44
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Leukotriene Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| RBL-1 | IC50 |
>45 μM
Compound: Rev-5901
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Compound was tested for its in vitro inhibitory activity against RBL-1 5-LO (insoluble above 45 uM)
Compound was tested for its in vitro inhibitory activity against RBL-1 5-LO (insoluble above 45 uM)
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[PMID: 3820229] |
REV 5901 (24 h) inhibits cell viability of CT26CL25 cells with an IC50 of 30 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 101910-24-1
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Appearance Solid
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분자량 335.44
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화학식 C22H25NO2
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Color White to off-white
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SMILES
OC(CCCCC)C1=CC=CC(OCC2=NC3=CC=CC=C3C=C2)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMF : 36 mg/mL (107.32 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Inwegen RGV, et, al. REV 5901: an orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile. J Pharmacol Exp Ther. 1987 Apr;241(1):117-24. [Content Brief]
[2]. Anderson G, et, al. Effects of REV 5901, a 5-lipoxygenase inhibitor and leukotriene antagonist, on pulmonary responses to platelet activating factor in the guinea-pig. Br J Pharmacol. 1988 Aug;94(4):1115-22. [Content Brief]
[3]. Paskaš S, et al. Carborane-Based Analog of Rev-5901 Attenuates Growth of Colon Carcinoma In Vivo. Molecules. 2022 Jul 14;27(14):4503. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 2.9812 mL | 14.9058 mL | 29.8116 mL | 74.5290 mL |
| 5 mM | 0.5962 mL | 2.9812 mL | 5.9623 mL | 14.9058 mL | |
| 10 mM | 0.2981 mL | 1.4906 mL | 2.9812 mL | 7.4529 mL | |
| 15 mM | 0.1987 mL | 0.9937 mL | 1.9874 mL | 4.9686 mL | |
| 20 mM | 0.1491 mL | 0.7453 mL | 1.4906 mL | 3.7264 mL | |
| 25 mM | 0.1192 mL | 0.5962 mL | 1.1925 mL | 2.9812 mL | |
| 30 mM | 0.0994 mL | 0.4969 mL | 0.9937 mL | 2.4843 mL | |
| 40 mM | 0.0745 mL | 0.3726 mL | 0.7453 mL | 1.8632 mL | |
| 50 mM | 0.0596 mL | 0.2981 mL | 0.5962 mL | 1.4906 mL | |
| 60 mM | 0.0497 mL | 0.2484 mL | 0.4969 mL | 1.2421 mL | |
| 80 mM | 0.0373 mL | 0.1863 mL | 0.3726 mL | 0.9316 mL | |
| 100 mM | 0.0298 mL | 0.1491 mL | 0.2981 mL | 0.7453 mL |
REV 5901 Related Classifications
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