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Cat. No.: HY-103557

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Ro 64-5229

Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. RO 64-5229 reduces the presynaptic inhibitory effect of Neuroligin 1.

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CAS No.: 246852-46-0
화학식: C₁₇H₁₉Cl₂N₃O
분자량:352.26

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Ro 64-5229 Chemical Structure

CAS No.: 246852-46-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. RO 64-5229 reduces the presynaptic inhibitory effect of Neuroligin 1^[1].

IC₅₀ & Target

mGlu2^[1].

All mGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.11 μM Compound: 1a	Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells	[PMID: 10465539]
CHO	IC₅₀	500 nM Compound: 1a	Inhibition of [3H]-DCG IV binding on rat mGluR2 transfected cell membranes from CHO cells Inhibition of [3H]-DCG IV binding on rat mGluR2 transfected cell membranes from CHO cells	[PMID: 10465539]

In Vitro

RO 64-5229 (50 µM) reduces the presynaptic inhibitory effect of NL1 (Neuroligin 1)^[1].
RO 64-5229 (0.1, 0.3, 1 µM; 20 min) inhibits the inhibitory activity of neuroligin 1 ectodomain (Ecto-NL1; mGluR2 activator) on Forskolin (Ecto-NL1 decreases the Forskolin-induced formation of cAMP) in HEK-mGluR2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

HEK-mGluR2 cells
Concentration:

0.1, 0.3, 1 µM
Incubation Time:

20 min
Result:

Inhibited activity of Ecto-NL1( mGluR2 activator).

Chemical Information

CAS No. 246852-46-0
분자량 352.26
화학식 C₁₇H₁₉Cl₂N₃O
SMILES

ClC1=C(/C(OC2CCCCCC2)=C/N3N=CN=C3)C(Cl)=CC=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gjørlund MD, et al. Soluble Ectodomain of Neuroligin 1 Decreases Synaptic Activity by Activating Metabotropic Glutamate Receptor 2. Front Mol Neurosci. 2017 May 3;10:116. [Content Brief]

Calculators

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Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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Ro 64-5229

High-Throughput Bioactive Compound Library

All mGluR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Ro 64-5229 Related Classifications

HY-103557 Related Classifications