Sarpogrelate
Based on 1 publication(s) in Google Scholar
Sarpogrelate (MCI-9042) is a new, specific orally active 5-HT2 receptor antagonist, Sarpogrelate increases platelet aggregation and has hemostasis effect, and can be used for the research of Buerger’s disease.
At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Sarpogrelate hydrochloride) usually boasts enhanced water solubility and stability.
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- CAS No.: 125926-17-2
- 화학식: C24H31NO6
- 분자량:429.51
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Other In-stock Forms of Sarpogrelate
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Sarpogrelate
MoreAll 5-HT Receptor Isoforms
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Biological Activity
제품 설명
IC50 & Target
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5-HT2 Receptor |
In Vitro
Sarpogrelate (MCI-9042) induces a significant decrease in plasma serotonin (5-HT) concentration and after 2 weeks increases significantly the concentration of whole blood 5-HT[1].
Sarpogrelate increases significantly plasma tryptophan concentration after 2 and 4 weeks, and no changes in plasma 5-HIAA concentration[1].
Sarpogrelate also has a tendency to increase the concentration of whole blood tryptophan concentration, did not show significant changes in platelet aggregation induced by ADP and collagen[1].
Sarpogrelate increases significantly platelet aggregation induced by serotonin after 2 weeks[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 125926-17-2
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분자량 429.51
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화학식 C24H31NO6
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SMILES
COC1=CC=CC(CCC2=CC=CC=C2OCC(CN(C)C)OC(CCC(O)=O)=O)=C1
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Synonyms
MCI-9042 free acid
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sarpogrelate Related Classifications
HY-10563 Related Classifications
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