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Cat. No.: HY-135439

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SB-203186

SB-203186 is a highly selective 5-HT₄ receptor antagonist. SB-203186 exhibits a potent competitive antagonistic effect, with its pK_B value being 8.3 in the isolated right atrium model of piglets. SB-203186 can dose-dependently shift the 5-HT-induced tachycardia curve to the right, and does not inhibit the maximum response. SB-203186 is an efficient 5-HT₄ antagonist in pig and human atria, but has no significant inhibitory effect in rat atria. SB-203186 can be used for the study of diseases such as arrhythmias and abnormal myocardial contraction.

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CAS No.: 135938-17-9
화학식: C₁₆H₂₀N₂O₂
분자량:272.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SB-203186 Chemical Structure

CAS No.: 135938-17-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

IC₅₀ & Target

^[1]

5-HT₄ Receptor

8.3 (pkB)

All 5-HT Receptor Isoforms :

Chemical Information

CAS No. 135938-17-9
분자량 272.34
화학식 C₁₆H₂₀N₂O₂
SMILES

O=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Medhurst AD, Kaumann AJ. Characterization of the 5‐HT4 receptor mediating tachycardia in piglet isolated right atrium. British journal of pharmacology. 1993 Nov;110(3):1023-30. [Content Brief]

[2]. Läer S, et al. Receptor mechanisms involved in the 5‐HT‐induced inotropic action in the rat isolated atrium. British journal of pharmacology. 1998 Mar;123(6):1182-8.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

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SB-203186

All 5-HT Receptor Isoforms

Biological Activity

제품 설명

IC50 & Target

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SB-203186 Related Classifications

HY-135439 Related Classifications

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