SRTCX1003
SRTCX1003 is an orally active SIRT1 activator. SRTCX1003 suppresses inflammatory responses.
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- CAS No.: 1203480-86-7
- 화학식: C23H23N5O3S
- 분자량:449.53
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
SIRT1[1]
SRTCX1003 (0-10 μM; 24 h) mediates a dose-dependent reduction of acetylated p65 protein in U2OS cells[1].
SRTCX1003 (5 μM; 6 h) attenuates TNFα-induced p65 acetylation in HEK 293T/17 cells[1].
SRTCX1003 (0-100 μM; 2 h) shows dose-dependent reduction of LPS (HY-D1056)-induced TNFα secretion from RAW cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK 293T/17
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Concentration:5 μM
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Incubation Time:6 h followed by 20 minutes TNFα stimulation
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Result:Significantly reduced TNFα-stimulated p65 acetylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c mice, LPS-induced inflammation mouse model[1]
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Dosage:3, 10, 30 and 100 mg/kg
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Administration:Oral, 60 minutes prior to LPS administration
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Result:Dose-dependently reduced LPS-stimulated TNFα and IL-12p40 production.
Chemical Information
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CAS No. 1203480-86-7
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분자량 449.53
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화학식 C23H23N5O3S
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SMILES
O=C(NC1=NC=CS1)C2=C3N=C(NC3=CC=C2)C4=CC=CC=C4OCCN5CCOCC5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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