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Cat. No.: HY-164956

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TB-9

TB-9, a Tasiamide B (HY-N15154) derivative, is a potent cathepsin D, cathepsin E, and BACE1 inhibitor with IC₅₀s of 0.0783 nM, 0.724 nM, and 54.2 nM, respectively.

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CAS No.: 1415033-91-8
화학식: C₅₅H₇₆N₈O₁₂
분자량:1041.24

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

TB-9 Chemical Structure

CAS No.: 1415033-91-8

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

TB-9, a Tasiamide B (HY-N15154) derivative, is a potent cathepsin D, cathepsin E, and BACE1 inhibitor with IC₅₀s of 0.0783 nM, 0.724 nM, and 54.2 nM, respectively^[1].

IC₅₀ & Target^[1]

Cathepsin D

0.0783 nM (IC₅₀)

Cathepsin E

0.724 nM (IC₅₀)

BACE1

54.2 nM (IC₅₀)

All Cathepsin Isoforms :

All Beta-secretase Isoforms :

BACE1
BACE2

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>10 μM Compound: TB-9	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay	[PMID: 35121401]
HepG2	IC₅₀	>10 μM Compound: TB-9	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay	[PMID: 35121401]
MDA-MB-231	IC₅₀	>10 μM Compound: TB-9	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay	[PMID: 35121401]

Chemical Information

CAS No. 1415033-91-8
분자량 1041.24
화학식 C₅₅H₇₆N₈O₁₂
SMILES

O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N(C)[C@@H](CCC(N)=O)C(N[C@@H](CC2=CC=CC=C2)[C@@H](O)CC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N(C)[C@H](CC3=CC=CC=C3)C(N4[C@@H](CCC4)C(OC)=O)=O)=O)=O)=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhi Li, et al. Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors. J Pept Sci. 2019 Apr;25(4):e3154. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

TB-9

All Cathepsin Isoforms

All Beta-secretase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

TB-9 Related Classifications

HY-164956 Related Classifications