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Cat. No.: HY-185764

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TCI 18

TCI 18 is a ligand of HSP72 with a K_i value of 4.7 μM. TCI 18 forms a covalent bond with Lys56 residue of HSP72 via a process involving initial reversible binding, conversion to a pre-covalent complex, and subsequent covalent bond formation. TCI 18 addresses the undruggable target HSP72.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2614310-11-9
화학식: C₂₇H₂₄FN₇O₇S
분자량:609.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

TCI 18 Chemical Structure

CAS No.: 2614310-11-9

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All HSP Isoforms :

In Vitro

TCI 18 (≤ 4.7 μM; 0.08-3 h) potently inhibits recombinant HSP72-NBD with a kinact/K_I of 93 M^-1s^-1, a kinact of 4.4 × 10^-4 s^-1, an initial K_i of 4.7 μM, and a t₁/₂ inf of 26 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2614310-11-9
분자량 609.59
화학식 C₂₇H₂₄FN₇O₇S
SMILES

NC1=NC=NC2=C1N=C(NCC3=CC(C=CC=N4)=C4C=C3)N2[C@H]5[C@H](O)[C@H](O)[C@@H](COC(C6=CC=C(S(F)(=O)=O)C=C6)=O)O5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Pettinger J, et al. Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72. Journal of medicinal chemistry. 2019 Dec 26;62(24):11383-11398. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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