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Cat. No.: HY-14154

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THRX-194556

THRX-194556 is a 5-HT₄ receptor agonist. THRX-194556 can be used to study gastrointestinal functional disorders and Alzheimer’s disease.

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CAS No.: 886579-13-1
화학식: C₂₈H₄₁N₅O₅S
분자량:559.72

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

THRX-194556 Chemical Structure

CAS No.: 886579-13-1

사이즈

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

THRX-194556 is a 5-HT₄ receptor agonist. THRX-194556 can be used to study gastrointestinal functional disorders and Alzheimer’s disease^[1]^[2].

IC₅₀ & Target^[1]

5-HT₄ Receptor

All 5-HT Receptor Isoforms :

Chemical Information

CAS No. 886579-13-1
분자량 559.72
화학식 C₂₈H₄₁N₅O₅S
SMILES

O=C1C(C(N[C@@H]2C[C@@H](N3C[C@@H](O)CN4CCN(S(C)(=O)=O)CC4)CC[C@@H]3C2)=O)=CC5=CC=CC=C5N1C(C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. A Multivalent Approach to the Design and Discovery of Orally Efficacious 5-HT4 Receptor Agonists J. Med. Chem., 2009, 52 (17), pp 5330-5343

[2]. Long DD, et al. Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT(4) receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6048-52. [Content Brief]

[3]. Long DD, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Goldblum AA, Humphrey PP, Marquess DG, et al. Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: clinical compound TD-2749. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4849-53. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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THRX-194556

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

THRX-194556 Related Classifications

HY-14154 Related Classifications