Ub4ix
Based on 1 Customer Validation
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.32%
- CAS No.: 2396736-46-0
- 화학식: C84H106N18O23S
- 분자량:1767.91
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2396736-46-0
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Appearance Solid
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분자량 1767.91
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화학식 C84H106N18O23S
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Color White to off-white
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Sequence
cyclo(Ac-{d-Trp}-Leu-Tyr-Leu-Asp-Asp-Ser-Gly-Asp-Trp-Trp-Ile-Cys)-Gly-NH2, cyclized via thioether
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Sequence Shortening
cyclo(Ac-{d-Trp}-LYLDDSGDWWIC)-G-NH2, cyclized via thioether
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 100 mg/mL (56.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Nawatha M, et al. De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains. Nat Chem. 2019 Jul;11(7):644-652. [Content Brief]
[2]. Saha A, et al. Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes. Acc Chem Res. 2023 Jul 18;56(14):1953-1965. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.5656 mL | 2.8282 mL | 5.6564 mL | 14.1410 mL |
| 5 mM | 0.1131 mL | 0.5656 mL | 1.1313 mL | 2.8282 mL | |
| 10 mM | 0.0566 mL | 0.2828 mL | 0.5656 mL | 1.4141 mL | |
| 15 mM | 0.0377 mL | 0.1885 mL | 0.3771 mL | 0.9427 mL | |
| 20 mM | 0.0283 mL | 0.1414 mL | 0.2828 mL | 0.7070 mL | |
| 25 mM | 0.0226 mL | 0.1131 mL | 0.2263 mL | 0.5656 mL | |
| 30 mM | 0.0189 mL | 0.0943 mL | 0.1885 mL | 0.4714 mL | |
| 40 mM | 0.0141 mL | 0.0707 mL | 0.1414 mL | 0.3535 mL | |
| 50 mM | 0.0113 mL | 0.0566 mL | 0.1131 mL | 0.2828 mL |
Ub4ix Related Classifications
HY-P10714 Related Classifications
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