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Cat. No.: HY-189144

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UNC5452

UNC5452 is a selective, ATP-competitive Nek1 kinase inhibitor with an IC₅₀ of 7.1 μM. UNC5452 inhibits IKKβ kinase activity. UNC5452 can be used for research on polycystic kidney disease.

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CAS No.: 943434-15-9
화학식: C₁₇H₂₀N₄O₂S
분자량:344.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

UNC5452 Chemical Structure

CAS No.: 943434-15-9

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

IKKβ	NEK1 7.1 μM (IC₅₀)

All NEKs Isoforms :

All IKK Isoforms :

In Vitro

UNC5452 (1 μM; 40 min) inhibits recombinant Nek1 activity by 63% at 1 μM in an ATP-dependent radiometric assay^[1].
UNC5452 inhibits recombinant Nek1 in a TR-FRET-based activity assay with an IC₅₀ of 7.1 μM^[1].
UNC5452 (1 μM) is a potent and selective Nek1 inhibitor (99.8% inhibition at 1 μM) with a narrow kinome profile, indicating that the 4-aryl-7-azaindole scaffold is a promising chemical starting point for Nek1-directed development^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 943434-15-9
분자량 344.43
화학식 C₁₇H₂₀N₄O₂S
SMILES

O=S(=O)(NCCN(C)C)C=1C=CC(=CC1)C=2C=CN=C3NC=CC32
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Baumann G, et al. Illuminating a Dark Kinase: Structure-Guided Design, Synthesis, and Evaluation of a Potent Nek1 Inhibitor and Its Effects on the Embryonic Zebrafish Pronephros. Journal of medicinal chemistry. 2022 Jan 27;65(2):1265-1282.

[2]. Wells CI, et al. In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases. MedChemComm. 2018 Jan 01;9(1):44-66.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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상품명:
CAS No.:
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Purity:
수량:

UNC5452

All NEKs Isoforms

All IKK Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

UNC5452 Related Classifications

HY-189144 Related Classifications

Bioz

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