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Cat. No.: HY-111089

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VJ115

VJ115 is a potent ENOX1 inhibitor with an EC₅₀ of 50 μM. By inhibiting ENOX1, VJ115 elevates NADH, which in turn downregulates the phosphorylation of p70S6K1/S6, alters the expression of c-Jun and cytoskeletal proteins, induces endothelial cells to lose polarization and migration ability, and increases caspase-3-dependent apoptosis under radiation. VJ115 can be used in studies related to solid tumors.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 929256-79-1
화학식: C₂₃H₂₄N₂O
분자량:344.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

VJ115 Chemical Structure

CAS No.: 929256-79-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

ENOX1

50 μM (EC₅₀)

p70S6K1

All NADPH Oxidase Isoforms :

All Ribosomal S6 Kinase (RSK) Isoforms :

All JNK Isoforms :

In Vitro

VJ115 (50 μM; 2-6 h) increases the intracellular NADH fluorescence level, inhibits the formation of capillary-like tubular structures, downregulates the mRNA and protein expressions of lamin A/C and stathmin, upregulates the mRNA and protein expressions of Hup1, and reduces the protein levels of phospho-cJun and phospho-p70S6K in HUVEC cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

human umbilical vein endothelial cells (HUVECs)
Concentration:

50 μM
Incubation Time:

6 h
Result:

Decreased lamin A/C mRNA by 37% relative to control.
Decreased stathmin mRNA by 88% relative to control.
Increased hypoxia up-regulated protein 1 (Hup1) mRNA by 38% relative to control.

Western Blot Analysis^[1]

Cell Line:

human umbilical vein endothelial cells (HUVECs)
Concentration:

50 μM
Incubation Time:

2 h; 6 h
Result:

Decreased stathmin protein by 40% relative to control after 6 h exposure.
Decreased lamin A/C protein by greater than 70% relative to control after 6 h exposure.
Increased Hup1 protein by 3.2-fold relative to control after 6 h exposure.
Reduced lamin A/C protein levels relative to control after 2 h exposure.
Inhibited phospho-cJun levels by 61% relative to control after 6 h exposure.
Downregulated phospho-p70S6K levels relative to control after 6 h exposure.

In Vivo

VJ115 inhibits developmental vasculogenesis in zebrafish embryos, phenocopying the effects of ENOX1 suppression^[1].
VJ115 acts as a radiation sensitizer, reducing tumor microvessel number and density and delaying syngeneic and xenograft tumor growth when combined with fractionated x-irradiation, while enhancing radiation-induced endothelial cell apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 929256-79-1
분자량 344.46
화학식 C₂₃H₂₄N₂O
SMILES

C(\C=1C=2C(N(CC3=CC=CC=C3)C1)=CC=CC2)=C/4\N5CCC(C4O)CC5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Venkateswaran A, et al. The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins. Investigational new drugs. 2013 Jun;31(3):535-44.

[2]. Geng L, et al. Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature. FASEB J. 2009 Sep;23(9):2986-95.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

VJ115

All NADPH Oxidase Isoforms

All Ribosomal S6 Kinase (RSK) Isoforms

All JNK Isoforms