WR 146459
Based on 1 Customer Validation
WR 146459 is an orally active 9-phenanthrenecarbinol and antimalarial agent. WR 146459 bears a 2-piperidyl substituent on its 9-carbinol moiety. WR 146459 inhibits hypoxanthine uptake by Plasmodium falciparum strains, reducing parasite viability. WR 146459 can be used for the research of malaria.
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- CAS No.: 50665-54-8
- 화학식: C21H18Cl2F3NO
- 분자량:428.27
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
All Parasite Isoforms
More
Biological Activity
제품 설명
IC50 & Target
[1]|
Plasmodium falciparum sporozoites |
In Vitro
WR 146459 (13.55-135.5 ng/mL) potently inhibits growth of Chloroquine (HY-17589A)-sensitive Plasmodium falciparum (Camp strain) with an ID50 of 2.14 ng/mL and Chloroquine-resistant Plasmodium falciparum (Smith strain) with an ID50 of 1.41 ng/mL in hypoxanthine uptake assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 50665-54-8
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Appearance Solid
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분자량 428.27
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화학식 C21H18Cl2F3NO
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SMILES
OC(C1=CC2=C(C3=CC(C(F)(F)F)=CC=C13)C=C(Cl)C=C2Cl)C4CCCCN4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 2.5 mg/mL (5.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
순도&문서
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3350 mL | 11.6749 mL | 23.3498 mL | 58.3744 mL |
| 5 mM | 0.4670 mL | 2.3350 mL | 4.6700 mL | 11.6749 mL |
WR 146459 Related Classifications
HY-185218 Related Classifications
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Keywords
- WR 146459
- 50665-54-8
- WR146459
- WR-146459
- Parasite
- owl monkey
- chloroquine-resistant Plasmodium falciparum (Smith strain)
- ICR/HA Swiss mice
- parasite viability
- Plasmodium berghei
- Plasmodium falciparum
- antimalarial agent
- malaria
- hypoxanthine uptake
- chloroquine-sensitive Plasmodium falciparum (Camp strain)
- Inhibitor
- inhibitor
- inhibit