LDC4297 hydrochloride
Based on 11 publication(s) in Google Scholar
LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. LDC4297 hydrochloride inhibits human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. LDC4297 hydrochloride shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC50 values of 0.02-1.21 μM. LDC4297 hydrochloride can be used for the research of infection.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.23%
- CAS. Nr.: 2319747-14-1
- Formel: C23H29ClN8O
- Molecular Weight:468.98
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) LDC4297 hydrochloride
More- Nat Commun. 2024 Mar 13;15(1):2265. [Abstract]
- J Clin Invest. 2025 Aug 12:e188839. [Abstract]
- Int J Biol Macromol. 2025 Mar:294:139117. [Abstract]
- Front Mol Biosci. 2021 Aug 19;8:697457. [Abstract]
- ChemMedChem. 2025 Aug 25:e202500448. [Abstract]
- Front Oncol. 2021 May 24;11:664848. [Abstract]
- SSRN. 2026 Jun 21.
- bioRxiv. 2025 Oct 11.
- SSRN. 2025 Apr 7.
- Freie Universität Berlin. 2023 Nov 29.
- bioRxiv. 2023 Apr 7.
Biologische Aktivität
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CDK7 0.13 nM (IC50) |
166v VP22-GFP 0.02 μM (EC50) |
01-6332 0.27 μM (EC50) |
HIV-1 (NL4.3 strain) 1.04 μM (EC50) |
4LIG7 1.13 μM (EC50) |
LDC4297 hydrochloride (0-10 μM; 6 d) dose-dependently inhibits HCMV replication with an EC50 value of 24.5 nM[1]. LDC4297 hydrochloride (0-10 μM; 4 d) shows anti-proliferative activity to primary cultures of fibroblasts derived from human (HFF) with a GI50 value of 4.5 μM[1]. LDC4297 hydrochloride (20 μM; 12-96 h) shows anti-HCMV activity through a multifaceted mode of action that involves an interference with virus-induced Rb phosphorylation[1]. LDC4297 hydrochloride (0-10 μM; 7 d) shows broad antiviral activities to HCMV, GPCMV, MCMV, HVV-6A, HSV-1, HSV-2, VZV, EBV, HAdV-2, Vaccinia virus, HIV-1 (nl4-3), HIV-1 (4LIG7) and Influenza A virus with EC50 values of 0.02, 0.05, 0.07, 0.04, 0.02, 0.27, 0.06, 1.21, 0.25, 0.77, 1.04, 1.13 and 0.99 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary cultures of fibroblasts derived from human (HFF) with virus infection
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Concentration:20 μM
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Incubation Time:12, 24, 48 and 96 hours
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Result:Showed inhibitory effect towards viral protein synthesis at the stage of immediate early (IE) gene expression and the drug-mediated reduction of IE1p72 levels partially recovered over time. Exerted an inhibitory effect on human cytomegalovirus (HCMV) induced an up-regulation of protein expression or protein phosphorylation, and reduced Rb expression in the uninfected control cells at 24 h.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 mice[1]
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Dosage:100 mg/kg
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Administration:Oral gavage; 100 mg/kg once
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Result:Showed a half-life (t1/2z) of 1.6 h, and the time to a mean peak plasma concentration of 1297.6 ng/mL is reached 0.5 h after administration with a continued presence in plasma for at least 8 h and a bioavailability of 97.7%.
Chemical Information
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CAS. Nr. 2319747-14-1
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Appearance Solid
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Molecular Weight 468.98
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Formel C23H29ClN8O
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Color White to off-white
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SMILES
CC(C)C1=C(N2N=C1)N=C(OC3CNCCC3)N=C2NCC4=CC=CC=C4N5C=CC=N5.[H]Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (11)
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Journal Impact Factor
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Most Recent
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Nat Commun
High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. [Abstract]2024 Mar 13;15(1):2265. PMID: 38480681 -
J Clin Invest
Dual targeting CDK4/6 and CDK7 augments tumor response and anti-tumor immunity in breast cancer models. [Abstract]2025 Aug 12:e188839. PMID: 40794455 -
Int J Biol Macromol
CDK2-based CDK7 mimic as a tool for structural analysis: Biochemical validation and crystal structure with SY5609. [Abstract]2025 Mar:294:139117. PMID: 39733900 -
Front Mol Biosci
2021 Aug 19;8:697457. PMID: 34490348 -
ChemMedChem
Novel Pyrazolo [1,5-a]-1,3,5-Triazine Derivatives as CDK7 Inhibitors: Synthesis and Biological Insights in Pancreatic Ductal Adenocarcinoma Models. [Abstract]2025 Aug 25:e202500448. PMID: 40853714 -
Front Oncol
Targeting Mutated p53 Dependency in Triple-Negative Breast Cancer Cells Through CDK7 Inhibition. [Abstract]2021 May 24;11:664848. PMID: 34109118 -
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Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (213.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1323 mL | 10.6614 mL | 21.3229 mL | 53.3072 mL |
| 5 mM | 0.4265 mL | 2.1323 mL | 4.2646 mL | 10.6614 mL | |
| 10 mM | 0.2132 mL | 1.0661 mL | 2.1323 mL | 5.3307 mL | |
| 15 mM | 0.1422 mL | 0.7108 mL | 1.4215 mL | 3.5538 mL | |
| 20 mM | 0.1066 mL | 0.5331 mL | 1.0661 mL | 2.6654 mL | |
| 25 mM | 0.0853 mL | 0.4265 mL | 0.8529 mL | 2.1323 mL | |
| 30 mM | 0.0711 mL | 0.3554 mL | 0.7108 mL | 1.7769 mL | |
| 40 mM | 0.0533 mL | 0.2665 mL | 0.5331 mL | 1.3327 mL | |
| 50 mM | 0.0426 mL | 0.2132 mL | 0.4265 mL | 1.0661 mL | |
| 60 mM | 0.0355 mL | 0.1777 mL | 0.3554 mL | 0.8885 mL | |
| 80 mM | 0.0267 mL | 0.1333 mL | 0.2665 mL | 0.6663 mL | |
| 100 mM | 0.0213 mL | 0.1066 mL | 0.2132 mL | 0.5331 mL |
LDC4297 hydrochloride Related Classifications
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