Cationic Lipids & Ionizable Lipids

TNT-b10 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). TNT-b10 is a carrier for both siRNA and mRNA.

cKK-E15 is a peptide-lipid that can be used to formulate LNP3 with C14PEG2000, unmodified cholesterol, and DOPE.

6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate is an ionizable lipid which can be used to make ALC-0315. The lipid has an ester bond adjacent to C6 relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver.

tert-Butyl 3-(7-((undecan-3-yloxy)carbonyl)heptylamino)propylcarbamate is an aminolipid featuring a Boc-protected primary amine, a propylamine spacer attached to an octanoate chain and a C11 chain.

C12-4 is an ionizable lipid for lipid nanoparticles (LNPs) formulation.

C12-SPM is a lipid that mediates siRNA delivery. C12-SPM has no significant cytotoxicity and can be used for research on hepatoviral diseases.

Bis(2-butyloctyl) 10-oxononadecanedioate is an ionizable lipid-like compound containing four hydrophobic tails bound by esters. It can be used to build lipids for mRNA encapsulation and delivery.

Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport.

Decanoyl-L-carnitine chloride is an ester derivative of L-carnitine, which is an important cofactor of fatty acid metabolism.

E12CA1A3 is a lipid transfection reagent that boosts the delivery efficiency of mRNA.

Ale-a12K4 is a peptide-derived ionizable lipid originating from a12K4. Ale-a12K4 mediates the targeted delivery of mRNA to bone tissues. Ale-a12K4 can be used for the preparation of lipid nanoparticles.

Am-Ka12K4 is a weakly positively charged peptide-based ionizable lipid. Am-Ka12K4 induces membrane disruption under endosomal pH conditions and possesses high lipid fusion capacity. Am-Ka12K4 forms tightly packed, stable lipid nanoparticles. Am-Ka12K4 mediates in vivo mRNA delivery, exhibits inherent liver tropism, and can be modified to adjust organ tropism, enabling selective mRNA delivery to the spleen, lung, or thymus. Am-Ka12K4 is applicable to research related to repetitive mild traumatic brain injury.

Oligomer-lipid 7C1 is an ionazable lipid. Oligomer-lipid 7C1 can be generated through the reaction of low-molecular-weight polyamine with lipid. Oligomer-lipid 7C1 efficiently binds siRNA to form nanoparticle. Oligomer-lipid 7C1 can induce RNA interference in endothelial cells of multiple organs in nonhuman primates. Oligomer-lipid 7C1 is able to deliver siRNA to endothelial cells and facilitates endothelial function modification in mouse models of vascular permeability, emphysema, primary tumor growth and metastasis.

nor-MC3 is an MC3-type ionizable lipid with C₁₇ unsaturated chains, formulated in lipid nanoparticles for nucleic acid (mRNA and siRNA) delivery and supports in vitro and in vivo transfection.

IR-19-Py is an ionizable lipid suitable for aerosolized mRNA delivery. When formulated into lipid nanoparticles, IR-19-Py delivers mRNA to nasal tissues in mice, achieving sustained nasal protein expression and dose-dependent pulmonary protein expression. IR-19-Py can be used in cystic fibrosis research.

F-L319 is an ionizable lipid and spleen-targeting mRNA delivery vector. F-L319 can be formulated into lipid nanoparticles (LNPs) to drive spleen-restricted reporter protein expression in mice. F-L319 modulates mRNA encapsulation efficiency, cellular uptake efficiency, and delivery efficiency, with effects varying depending on the composition of LNP formulations. When prepared as pure LNPs, F-L319 shows poor mRNA delivery efficiency in cells; in contrast, hybrid LNPs containing F-L319 and L319 significantly enhance mRNA delivery efficiency in cells.

C14-306 is an ionizable lipid with a linear 306 amine core and a C14 alkyl tail. C14-306 enhances brain transfection efficiency. Lipid nanoparticles (LNP) formulated with C14-306 promote mRNA delivery, increase neuronal transfection rate, and facilitate Cre-mediated recombination in the brain, while reducing off-target expression in the liver.

10A1P16 is an ionizable phospholipid composed of a tertiary amine, a phosphate group and three hydrophobic tails. As a spleen-selective RNA delivery vector, 10A1P16 successfully transfects approximately 30% of splenic macrophages and 6% of splenic B cells in vivo. 10A1P16 can be used to prepare spleen-selective 10A1P16-MDOA lipid nanoparticles, which effectively mediate mRNA delivery and gene editing in mouse models. This delivery system retains potent spleen-targeted mRNA delivery efficacy and can be applied to ovarian cancer research.

A-066 (Formula I) is a cationic lipid. A-066 forms Cationic-Based Lipid Encapsulation Systems (CaBLES) or Lipid-Based Particles. A-066 facilitates delivery of nucleic acids and other agents.

N-Methyldioctadecylamine (Dioctadecylmethylamine; MDOA) is a surfactant and an ionizable cationic helper lipid that can be used for the preparation of lipid nanoparticles. When used in combination with iPhos 9A1P9 (HY-W590683) in ionizable lipid nanoparticles (iPLNPs), N-Methyldioctadecylamine enables liver-selective mRNA expression. N-Methyldioctadecylamine supports initial in vitro and in vivo mRNA delivery screening for iPhos lipids.