2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. LY459477

LY459477 is a potent, selective and orally active metabotropic glutamate 2/3 receptor (mGluR2/3) agonist. LY459477 can effectively suppress Phencyclidine-evoked locomotor activity at doses that do not impair neuromuscular coordination. LY459477 can be used for the research of neurological disease.

For research use only. We do not sell to patients.

LY459477

LY459477 Chemical Structure

CAS No. : 635318-20-6

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Description

LY459477 is a potent, selective and orally active metabotropic glutamate 2/3 receptor (mGluR2/3) agonist. LY459477 can effectively suppress Phencyclidine-evoked locomotor activity at doses that do not impair neuromuscular coordination. LY459477 can be used for the research of neurological disease[1].

IC50 & Target[1]

mGluR2

 

mGluR3

 

Molecular Weight

203.17

Formula

C8H10FNO4
CAS No.
SMILES

OC([C@]1([C@@]2([H])[C@]([C@@H](C1)F)([H])[C@@H]2C(O)=O)N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LY459477 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY459477635318-20-6LY 459477LY-459477mGluRMetabotropic glutamate receptorsmetabotropic glutamate 2/3 receptorphencyclidineneuromuscularneurological diseaseInhibitorinhibitorinhibit

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