1. NF-κB
    Apoptosis
  2. IKK
    NF-κB
    Apoptosis
  3. Malachite green oxalate

Malachite green oxalate 

Cat. No.: HY-D0162 Purity: >98.0%
Handling Instructions

Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo.

For research use only. We do not sell to patients.

Malachite green oxalate Chemical Structure

Malachite green oxalate Chemical Structure

CAS No. : 2437-29-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo[1][2][3].

IC50 & Target

IKBKE[3]

Molecular Weight

463.50

Formula

C₂₃H₂₅N₂.₁/₂C₂H₂O₄.C₂HO₄

CAS No.

2437-29-8

SMILES

C/[N+](C)=C1C=C/C(C=C/1)=C(C2=CC=C(N(C)C)C=C2)\C3=CC=CC=C3.O=C(O)C([O-])=O.O=C(O)C(O)=O.[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (53.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1575 mL 10.7875 mL 21.5750 mL
5 mM 0.4315 mL 2.1575 mL 4.3150 mL
10 mM 0.2157 mL 1.0787 mL 2.1575 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Malachite greenIKKNF-κBApoptosisIκB kinaseI kappa B kinase Nuclear factor-κBNuclear factor-kappaBphosphateenzymaticIKBKEIκBαp65IRF3antitumorInhibitorinhibitorinhibit

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Product Name:
Malachite green oxalate
Cat. No.:
HY-D0162
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